%0 Journal Article
%T High-resolution and highly accelerated MRI T2 mapping as a tool to characterise renal tumour subtypes and grades.
%A Horvat-Menih I
%A Li H
%A Priest AN
%A Li S
%A Gill AB
%A Mendichovszky IA
%A Francis ST
%A Warren AY
%A O'Carrigan B
%A Welsh SJ
%A Jones JO
%A Riddick ACP
%A Armitage JN
%A Mitchell TJ
%A Stewart GD
%A Gallagher FA
%J Eur Radiol Exp
%V 8
%N 1
%D 2024 Jul 10
%M 38981998
暂无%R 10.1186/s41747-024-00476-8
%X <B>BACKGROUND: </B>Clinical imaging tools to probe aggressiveness of renal masses are lacking, and T2-weighted imaging as an integral part of magnetic resonance imaging protocol only provides qualitative information. We developed high-resolution and accelerated T2 mapping methods based on echo merging and using k-t undersampling and reduced flip angles (TEMPURA) and tested their potential to quantify differences between renal tumour subtypes and grades.<BR><B>METHODS: </B>Twenty-four patients with treatment-naïve renal tumours were imaged: seven renal oncocytomas (RO); one eosinophilic/oncocytic renal cell carcinoma; two chromophobe RCCs (chRCC); three papillary RCCs (pRCC); and twelve clear cell RCCs (ccRCC). Median, kurtosis, and skewness of T2 were quantified in tumours and in the normal-adjacent kidney cortex and were compared across renal tumour subtypes and between ccRCC grades.<BR><B>RESULTS: </B>High-resolution TEMPURA depicted the tumour structure at improved resolution compared to conventional T2-weighted imaging. The lowest median T2 values were present in pRCC (high-resolution, 51 ms; accelerated, 45 ms), which was significantly lower than RO (high-resolution; accelerated, p = 0.012) and ccRCC (high-resolution, p = 0.019; accelerated, p = 0.008). ROs showed the lowest kurtosis (high-resolution, 3.4; accelerated, 4.0), suggestive of low intratumoural heterogeneity. Lower T2 values were observed in higher compared to lower grade ccRCCs (grades 2, 3 and 4 on high-resolution, 209 ms, 151 ms, and 106 ms; on accelerated, 172 ms, 160 ms, and 102 ms, respectively), with accelerated TEMPURA showing statistical significance in comparison (p = 0.037).<BR><B>CONCLUSIONS: </B>Both high-resolution and accelerated TEMPURA showed marked potential to quantify differences across renal tumour subtypes and between ccRCC grades.<BR><B>BACKGROUND: </B>ClinicalTrials.gov, NCT03741426 . Registered on 13 November 2018.<BR><B>CONCLUSIONS: </B>The newly developed T2 mapping methods have improved resolution, shorter acquisition times, and promising quantifiable readouts to characterise incidental renal masses.