{Reference Type}: Journal Article
{Title}: High-resolution and highly accelerated MRI T2 mapping as a tool to characterise renal tumour subtypes and grades.
{Author}: Horvat-Menih I;Li H;Priest AN;Li S;Gill AB;Mendichovszky IA;Francis ST;Warren AY;O'Carrigan B;Welsh SJ;Jones JO;Riddick ACP;Armitage JN;Mitchell TJ;Stewart GD;Gallagher FA;
{Journal}: Eur Radiol Exp
{Volume}: 8
{Issue}: 1
{Year}: 2024 Jul 10
暂无{DOI}: 10.1186/s41747-024-00476-8
{Abstract}: <B>BACKGROUND: </B>Clinical imaging tools to probe aggressiveness of renal masses are lacking, and T2-weighted imaging as an integral part of magnetic resonance imaging protocol only provides qualitative information. We developed high-resolution and accelerated T2 mapping methods based on echo merging and using k-t undersampling and reduced flip angles (TEMPURA) and tested their potential to quantify differences between renal tumour subtypes and grades.<BR><B>METHODS: </B>Twenty-four patients with treatment-naïve renal tumours were imaged: seven renal oncocytomas (RO); one eosinophilic/oncocytic renal cell carcinoma; two chromophobe RCCs (chRCC); three papillary RCCs (pRCC); and twelve clear cell RCCs (ccRCC). Median, kurtosis, and skewness of T2 were quantified in tumours and in the normal-adjacent kidney cortex and were compared across renal tumour subtypes and between ccRCC grades.<BR><B>RESULTS: </B>High-resolution TEMPURA depicted the tumour structure at improved resolution compared to conventional T2-weighted imaging. The lowest median T2 values were present in pRCC (high-resolution, 51 ms; accelerated, 45 ms), which was significantly lower than RO (high-resolution; accelerated, p = 0.012) and ccRCC (high-resolution, p = 0.019; accelerated, p = 0.008). ROs showed the lowest kurtosis (high-resolution, 3.4; accelerated, 4.0), suggestive of low intratumoural heterogeneity. Lower T2 values were observed in higher compared to lower grade ccRCCs (grades 2, 3 and 4 on high-resolution, 209 ms, 151 ms, and 106 ms; on accelerated, 172 ms, 160 ms, and 102 ms, respectively), with accelerated TEMPURA showing statistical significance in comparison (p = 0.037).<BR><B>CONCLUSIONS: </B>Both high-resolution and accelerated TEMPURA showed marked potential to quantify differences across renal tumour subtypes and between ccRCC grades.<BR><B>BACKGROUND: </B>ClinicalTrials.gov, NCT03741426 . Registered on 13 November 2018.<BR><B>CONCLUSIONS: </B>The newly developed T2 mapping methods have improved resolution, shorter acquisition times, and promising quantifiable readouts to characterise incidental renal masses.