Abstract：
Frailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used the Frailty Index (FI) definition to (1) investigate the association between levels of inflammatory markers (baseline) and change in FI score after 8 years of follow-up and (2) investigate the longitudinal associations between inflammatory markers, body composition, and frailty. Home-dwelling elderly (≥ 70 years) were invited to participate in the study and re-invited to a follow-up visit 8 years later. This study includes a total of 133 participants. The inflammatory markers included were high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and glycoprotein acetyls (Gp-acetyls). We used the body composition markers fat mass, fat-free mass, and waist circumference. The FI score consisted of 38 variables. Additional clinical assessments such as blood pressure and body mass index (BMI), as well as information about daily medications, were collected at both visits. Linear regression model and Spearman\'s rank correlation were used to investigate associations. We showed that the FI score increased after 8 years, and participants with higher hs-CRP levels at baseline had the largest change in the FI score. Changes in fat mass were significantly correlated with changes in hs-CRP and IL-6, and changes in waist circumference were significantly correlated with changes in TNF-α. The use of drugs increased during the 8 years of follow-up, which may have attenuated the associations between inflammation and frailty. However, elevated concentrations of hs-CRP in the elderly may be associated with an increased risk of frailty in subsequent years.
摘要：
虚弱与炎症和身体成分的变化有关，但是调查结果不一致。为了探索这个，我们使用衰弱指数（FI）定义为（1）研究炎症标志物水平（基线）与随访8年后FI评分变化之间的关联；（2）研究炎症标志物之间的纵向关联，身体成分,和脆弱。家庭老年人（≥70岁）被邀请参加研究，并在8年后再次被邀请进行随访。这项研究共包括133名参与者。炎性标志物包括高敏C反应蛋白(hs-CRP),白细胞介素6（IL-6），肿瘤坏死因子α（TNF-α），和糖蛋白乙酰基（Gp-乙酰基）。我们用身体成分标记脂肪量，无脂质量，和腰围。FI评分由38个变量组成。其他临床评估，如血压和体重指数（BMI），以及关于日常药物的信息，在两次访问中都被收集。采用线性回归模型和Spearman秩相关研究。我们发现8年后FI得分增加，基线时hs-CRP水平较高的参与者的FI评分变化最大.脂肪量的变化与hs-CRP、IL-6的变化显著相关,腰围的变化与TNF-α的变化显著相关。在随访的8年中，药物的使用有所增加，这可能减弱了炎症和虚弱之间的关联。然而,老年人hs-CRP浓度升高可能与随后几年的虚弱风险增加相关.
