基于生理的动力学建模 - 促进体外定量到体内外推 , 以预测芦荟大黄素在大鼠和人类中的作用。
关键词: hepatotoxicity nephrotoxicity nuclear factor erythroid 2-related factor 2 (Nrf2) physiologically based kinetic (PBK) modeling quantitative in vitro to in vivo extrapolation (QIVIVE) reactive oxidative stress (ROS)
Mesh : Animals Humans Rats Kidney / metabolism drug effects Anthraquinones / chemistry metabolism Liver / metabolism drug effects Kinetics Male Models, Biological Reactive Oxygen Species / metabolism NF-E2-Related Factor 2 / metabolism genetics Dietary Supplements / analysis Aloe / chemistry metabolism Rats, Sprague-Dawley Female
来 源:
DOI:10.1021/acs.jafc.4c00969
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