Abstract：
OBJECTIVE: Allergy diagnostics and immunotherapeutics in Asia heavily rely on imported products from Western countries, raising concerns about the accuracy and efficacy of these products for the management of Asian allergy patients.
RESULTS: Recent advancements in allergen research have led to the identification and characterization of novel allergens from indigenous Korean species. While some allergens share homology with well-known allergens, others lack counterparts in imported allergen extracts. Classifying regional allergens in Asia into three categories based on their cross-reactivity with imported allergens offers valuable insights. Highly cross-reactive allergens, such as oak allergens Que m 1 from Quercus mongolica and Que ac 1 from Q. acutissima, can be effectively substituted with the imported allergens. Allergens with partial cross-reactivity, like the Asian needle ant allergen Pac c 3 (Antigen 5), permit limited diagnostic value by the currently available products. Unique allergens, including the Japanese hop allergen Hum j 6 (pectin methylesterase inhibitor) and the silkworm pupa allergen Bomb m 4 (30 kDa hemolymph lipoprotein) lack alternatives in the available product list. Greater attention is needed, particularly for species listed as ecologically invasive in Western regions. Additionally, allergens from domestic fruits and vegetables causing pollen food allergy syndrome require characterization for the development of improved diagnostics.
RESULTS: Recent advancements in allergen research have led to the identification and characterization of novel allergens from indigenous Korean species. While some allergens share homology with well-known allergens, others lack counterparts in imported allergen extracts. Classifying regional allergens in Asia into three categories based on their cross-reactivity with imported allergens offers valuable insights. Highly cross-reactive allergens, such as oak allergens Que m 1 from Quercus mongolica and Que ac 1 from Q. acutissima, can be effectively substituted with the imported allergens. Allergens with partial cross-reactivity, like the Asian needle ant allergen Pac c 3 (Antigen 5), permit limited diagnostic value by the currently available products. Unique allergens, including the Japanese hop allergen Hum j 6 (pectin methylesterase inhibitor) and the silkworm pupa allergen Bomb m 4 (30 kDa hemolymph lipoprotein) lack alternatives in the available product list. Greater attention is needed, particularly for species listed as ecologically invasive in Western regions. Additionally, allergens from domestic fruits and vegetables causing pollen food allergy syndrome require characterization for the development of improved diagnostics.
摘要：
目的：亚洲的过敏诊断和免疫治疗严重依赖西方国家的进口产品，引起人们对这些产品用于亚洲过敏患者管理的准确性和有效性的担忧。
结果：过敏原研究的最新进展已导致对来自韩国本土物种的新型过敏原的鉴定和表征。虽然一些过敏原与众所周知的过敏原具有同源性，其他人缺乏进口过敏原提取物。根据与进口过敏原的交叉反应，将亚洲的地区过敏原分为三类，可以提供宝贵的见解。高度交叉反应的过敏原，例如来自蒙古Quercus的橡木过敏原Quem1和来自Q.acutissima的Queac1，可有效替代进口过敏原。具有部分交叉反应性的过敏原，像亚洲针过敏原Pacc3（抗原5），允许当前可用产品的有限诊断价值。独特的过敏原，包括日本啤酒花过敏原Humj6（果胶甲酯酶抑制剂）和蚕蛹过敏原Bombm4（30kDa血淋巴脂蛋白）在可用产品列表中缺乏替代品。需要更多的关注，特别是在西部地区被列为生态入侵的物种。此外,引起花粉食物过敏综合征的国内水果和蔬菜的过敏原需要表征以开发改进的诊断方法。
结果：过敏原研究的最新进展已导致对来自韩国本土物种的新型过敏原的鉴定和表征。虽然一些过敏原与众所周知的过敏原具有同源性，其他人缺乏进口过敏原提取物。根据与进口过敏原的交叉反应，将亚洲的地区过敏原分为三类，可以提供宝贵的见解。高度交叉反应的过敏原，例如来自蒙古Quercus的橡木过敏原Quem1和来自Q.acutissima的Queac1，可有效替代进口过敏原。具有部分交叉反应性的过敏原，像亚洲针过敏原Pacc3（抗原5），允许当前可用产品的有限诊断价值。独特的过敏原，包括日本啤酒花过敏原Humj6（果胶甲酯酶抑制剂）和蚕蛹过敏原Bombm4（30kDa血淋巴脂蛋白）在可用产品列表中缺乏替代品。需要更多的关注，特别是在西部地区被列为生态入侵的物种。此外,引起花粉食物过敏综合征的国内水果和蔬菜的过敏原需要表征以开发改进的诊断方法。
