PDF(Pubmed)
Abstract：
A catalyst- and additive-free synthesis of 2-benzyl N-substituted anilines from (E)-2-arylidene-3-cyclohexenones and primary amines has been reported. The reaction proceeds smoothly through a sequential imine condensation-isoaromatization pathway, affording a series of synthetically useful aniline derivatives in acceptable to high yields. Mild reaction conditions, no requirement of metal catalysts, operational simplicity and the potential for scale-up production are some of the highlighted advantages of this transformation.
摘要：
已经报道了由（E）-2-亚芳基-3-环己烯酮和伯胺无催化剂和添加剂合成2-苄基N-取代的苯胺。反应通过顺序的亚胺缩合-异芳构化途径顺利进行，以可接受的至高收率提供一系列合成有用的苯胺衍生物。温和的反应条件,不需要金属催化剂，操作简单和扩大生产的潜力是这种转变的一些突出优势。
