%0 Journal Article
%T Synthesis of 2-benzyl N-substituted anilines via imine condensation-isoaromatization of (E)-2-arylidene-3-cyclohexenones and primary amines.
%A Li L
%A Li N
%A Mo XT
%A Yuan MW
%A Jiang L
%A Yuan ML
%J Beilstein J Org Chem
%V 20
%N 0
%D 2024
%M 38978743
%F 2.544
%R 10.3762/bjoc.20.130
%X A catalyst- and additive-free synthesis of 2-benzyl N-substituted anilines from (E)-2-arylidene-3-cyclohexenones and primary amines has been reported. The reaction proceeds smoothly through a sequential imine condensation-isoaromatization pathway, affording a series of synthetically useful aniline derivatives in acceptable to high yields. Mild reaction conditions, no requirement of metal catalysts, operational simplicity and the potential for scale-up production are some of the highlighted advantages of this transformation.