{Reference Type}: Journal Article
{Title}: Synthesis of 2-benzyl N-substituted anilines via imine condensation-isoaromatization of (E)-2-arylidene-3-cyclohexenones and primary amines.
{Author}: Li L;Li N;Mo XT;Yuan MW;Jiang L;Yuan ML;
{Journal}: Beilstein J Org Chem
{Volume}: 20
{Issue}: 0
{Year}: 2024
{Factor}: 2.544
{DOI}: 10.3762/bjoc.20.130
{Abstract}: A catalyst- and additive-free synthesis of 2-benzyl N-substituted anilines from (E)-2-arylidene-3-cyclohexenones and primary amines has been reported. The reaction proceeds smoothly through a sequential imine condensation-isoaromatization pathway, affording a series of synthetically useful aniline derivatives in acceptable to high yields. Mild reaction conditions, no requirement of metal catalysts, operational simplicity and the potential for scale-up production are some of the highlighted advantages of this transformation.