Abstract：
OBJECTIVE: To evaluate the effects of a water drinking test (WDT) on the intraocular pressure (IOP) and vascular density of the optic nerve head and macula in healthy individuals and those with primary open glaucoma using optical coherence tomography angiography.
METHODS: In this prospective comparative study, 30 healthy patients and 44 POAG subjects were divided into two groups. The study\'s outcome measures were the IOP and vessel density of the optic nerve and macular area. After ingesting 1000 ml of water in 5 min, the effect of the WDT on the IOP and the vascular density of the macular area and optic nerve head were measured at baseline and then 20, 40, and 60 min later at intervals of 20 min.
RESULTS: The initial IOP in the healthy and glaucomatous eye groups was comparable (15.94 ± 2.6 and 16.87 ± 4.21 mmHg, respectively, P = 0.506). The IOP of both groups peaked at 40\' measurements. POAG eyes had significantly higher IOP elevation (4.34 ± 0.30 vs. 2.24 ± 0.30 mmHg, P < 0.001). The glaucomatous eyes had lower radial peripapillary capillary (RPC) and whole macular superficial capillary plexus (SCP) densities at baseline (48.55 ± 5.99 vs. 51.33 ± 3.75) and (48.92 ± 3.41 vs. 45.29 ± 5.29), respectively (P < 0.001). After the WDT, the change in vessel density between groups in the RPC, whole superficial, and deep capillary plexuses was insignificant (SCP and DCP of 0.66 and 0.70, respectively, P = 0.16).
CONCLUSIONS: The WDT caused a significant IOP jump in both glaucomatous and healthy eyes, but generally, the alterations in the glaucomatous eyes were more pronounced. The changes in vascular density in the macula and optic nerve head were similar between the groups.
METHODS: In this prospective comparative study, 30 healthy patients and 44 POAG subjects were divided into two groups. The study\'s outcome measures were the IOP and vessel density of the optic nerve and macular area. After ingesting 1000 ml of water in 5 min, the effect of the WDT on the IOP and the vascular density of the macular area and optic nerve head were measured at baseline and then 20, 40, and 60 min later at intervals of 20 min.
RESULTS: The initial IOP in the healthy and glaucomatous eye groups was comparable (15.94 ± 2.6 and 16.87 ± 4.21 mmHg, respectively, P = 0.506). The IOP of both groups peaked at 40\' measurements. POAG eyes had significantly higher IOP elevation (4.34 ± 0.30 vs. 2.24 ± 0.30 mmHg, P < 0.001). The glaucomatous eyes had lower radial peripapillary capillary (RPC) and whole macular superficial capillary plexus (SCP) densities at baseline (48.55 ± 5.99 vs. 51.33 ± 3.75) and (48.92 ± 3.41 vs. 45.29 ± 5.29), respectively (P < 0.001). After the WDT, the change in vessel density between groups in the RPC, whole superficial, and deep capillary plexuses was insignificant (SCP and DCP of 0.66 and 0.70, respectively, P = 0.16).
CONCLUSIONS: The WDT caused a significant IOP jump in both glaucomatous and healthy eyes, but generally, the alterations in the glaucomatous eyes were more pronounced. The changes in vascular density in the macula and optic nerve head were similar between the groups.
摘要：
目的：使用光学相干断层扫描血管造影术评估饮水试验（WDT）对健康个体和原发性开放性青光眼患者的眼内压（IOP）和视神经乳头和黄斑血管密度的影响。
方法：在这项前瞻性比较研究中，将30例健康患者和44例POAG受试者分为两组。该研究的结果测量为眼压和视神经和黄斑区的血管密度。在5分钟内摄入1000毫升水后，在基线时,然后在20,40和60min后,每隔20min测量WDT对眼压和黄斑区和视神经乳头血管密度的影响.
结果：健康眼组和青光眼眼组的初始IOP相当（15.94±2.6和16.87±4.21mmHg，分别,P=0.506）。两组的IOP在40°时达到峰值。POAG眼IOP升高明显较高（4.34±0.30vs.2.24±0.30mmHg，P<0.001)。青光眼在基线时具有较低的放射状乳头周围毛细血管（RPC）和整个黄斑浅表毛细血管丛（SCP）密度（48.55±5.99vs.51.33±3.75）和（48.92±3.41vs.45.29±5.29),分别(P<0.001)。在WDT之后,RPC中各组之间血管密度的变化，整个肤浅，深毛细血管丛不显著(SCP和DCP分别为0.66和0.70，P=0.16）。
结论：WDT导致青光眼和健康眼睛的IOP均出现明显的跳跃，但总的来说，青光眼的改变更为明显。两组之间黄斑和视神经乳头血管密度的变化相似。
方法：在这项前瞻性比较研究中，将30例健康患者和44例POAG受试者分为两组。该研究的结果测量为眼压和视神经和黄斑区的血管密度。在5分钟内摄入1000毫升水后，在基线时,然后在20,40和60min后,每隔20min测量WDT对眼压和黄斑区和视神经乳头血管密度的影响.
结果：健康眼组和青光眼眼组的初始IOP相当（15.94±2.6和16.87±4.21mmHg，分别,P=0.506）。两组的IOP在40°时达到峰值。POAG眼IOP升高明显较高（4.34±0.30vs.2.24±0.30mmHg，P<0.001)。青光眼在基线时具有较低的放射状乳头周围毛细血管（RPC）和整个黄斑浅表毛细血管丛（SCP）密度（48.55±5.99vs.51.33±3.75）和（48.92±3.41vs.45.29±5.29),分别(P<0.001)。在WDT之后,RPC中各组之间血管密度的变化，整个肤浅，深毛细血管丛不显著(SCP和DCP分别为0.66和0.70，P=0.16）。
结论：WDT导致青光眼和健康眼睛的IOP均出现明显的跳跃，但总的来说，青光眼的改变更为明显。两组之间黄斑和视神经乳头血管密度的变化相似。
