PDF(Pubmed)
Abstract：
BACKGROUND: Black emerging adults (18-28 years) have the highest risk of short sleep duration and obesity. This increased risk may be partly explained by greater stress levels, which may result from race-related stress (racial discrimination and heightened race-related vigilance) or living in more disadvantaged home and neighbourhood environments. Insufficient sleep may also impact obesity risk via several weight-related mechanisms including energy balance, appetite and food reward, cortisol profiles and hydration status. This paper describes the rationale, design and methods for the Sleep, Health Outcomes and Body Weight (SHOW) study. This study aims to prospectively assess the effects of sleep, race-related stress and home/neighbourhood environments on weight-related mechanisms and obesity markers (body weight, waist circumference and fat mass) in 150 black emerging adults.
METHODS: The SHOW study follows a measurement burst design that includes 3, 7-day data collection bursts (baseline, 6-month and 12-month follow-ups). Sleep is measured with three methods: sleep diary, actigraphy and polysomnography. Energy balance over 7 days is based on resting and postprandial energy expenditure measured via indirect calorimetry, physical activity via accelerometry and self-reported and ad libitum energy intake methods. Self-reported methods and blood biomarkers assess fasting and postprandial appetite profiles and a behavioural-choice task measures food reward. Cortisol awakening response and diurnal cortisol profiles over 3 days are assessed via saliva samples and chronic cortisol exposure via a hair sample. Hydration markers are assessed with 24-hour urine collection over 3 days and fasting blood biomarkers. Race-related stress is self-reported over 7 days. Home and neighbourhood environments (via the Windshield Survey) is observer assessed.
BACKGROUND: Ethics approval was granted by the University of North Carolina at Greensboro\'s Institutional Review Board. Study findings will be disseminated through peer-reviewed publications, presentations at scientific meetings and reports, briefs/infographics for lay and community audiences.
METHODS: The SHOW study follows a measurement burst design that includes 3, 7-day data collection bursts (baseline, 6-month and 12-month follow-ups). Sleep is measured with three methods: sleep diary, actigraphy and polysomnography. Energy balance over 7 days is based on resting and postprandial energy expenditure measured via indirect calorimetry, physical activity via accelerometry and self-reported and ad libitum energy intake methods. Self-reported methods and blood biomarkers assess fasting and postprandial appetite profiles and a behavioural-choice task measures food reward. Cortisol awakening response and diurnal cortisol profiles over 3 days are assessed via saliva samples and chronic cortisol exposure via a hair sample. Hydration markers are assessed with 24-hour urine collection over 3 days and fasting blood biomarkers. Race-related stress is self-reported over 7 days. Home and neighbourhood environments (via the Windshield Survey) is observer assessed.
BACKGROUND: Ethics approval was granted by the University of North Carolina at Greensboro\'s Institutional Review Board. Study findings will be disseminated through peer-reviewed publications, presentations at scientific meetings and reports, briefs/infographics for lay and community audiences.
摘要：
背景：黑人新兴成年人（18-28岁）睡眠时间短和肥胖的风险最高。这种增加的风险可能部分解释为更大的压力水平，这可能是由于与种族有关的压力(种族歧视和提高与种族有关的警惕性)或生活在更不利的家庭和邻里环境中造成的。睡眠不足也可能通过几种与体重相关的机制影响肥胖风险，包括能量平衡。食欲和食物奖励，皮质醇概况和水合状态。本文描述了理论基础，睡眠的设计和方法，健康结果和体重（SHOW）研究。这项研究旨在前瞻性地评估睡眠的影响，与种族相关的压力和家庭/邻里环境对体重相关机制和肥胖标志物(体重，腰围和脂肪量）在150个黑人新兴成年人中。
方法：SHOW研究遵循测量突发设计，其中包括3、7天的数据收集突发（基线，6个月和12个月的随访)。用三种方法测量睡眠：睡眠日记，活动图和多导睡眠图。7天的能量平衡基于通过间接量热法测量的静息和餐后能量消耗，通过加速度测量和自我报告和随意摄入能量的方法进行身体活动。自我报告的方法和血液生物标志物评估空腹和餐后食欲概况，行为选择任务衡量食物奖励。通过唾液样品和通过毛发样品的慢性皮质醇暴露评估3天的皮质醇觉醒反应和昼夜皮质醇谱。用3天的24小时尿液收集和空腹血液生物标志物来评估水合标志物。与种族相关的压力在7天内自我报告。家庭和邻里环境(通过挡风玻璃测量)由观察者评估。
背景：伦理批准是由北卡罗来纳大学格林斯伯勒大学的机构审查委员会批准的。研究结果将通过同行评审的出版物传播，在科学会议和报告中的演讲，为外行和社区观众提供的简报/信息图表。
方法：SHOW研究遵循测量突发设计，其中包括3、7天的数据收集突发（基线，6个月和12个月的随访)。用三种方法测量睡眠：睡眠日记，活动图和多导睡眠图。7天的能量平衡基于通过间接量热法测量的静息和餐后能量消耗，通过加速度测量和自我报告和随意摄入能量的方法进行身体活动。自我报告的方法和血液生物标志物评估空腹和餐后食欲概况，行为选择任务衡量食物奖励。通过唾液样品和通过毛发样品的慢性皮质醇暴露评估3天的皮质醇觉醒反应和昼夜皮质醇谱。用3天的24小时尿液收集和空腹血液生物标志物来评估水合标志物。与种族相关的压力在7天内自我报告。家庭和邻里环境(通过挡风玻璃测量)由观察者评估。
背景：伦理批准是由北卡罗来纳大学格林斯伯勒大学的机构审查委员会批准的。研究结果将通过同行评审的出版物传播，在科学会议和报告中的演讲，为外行和社区观众提供的简报/信息图表。
