Abstract：
Circular dichroism (CD) spectroscopy has been extensively utilized for detecting and distinguishing the chirality of diverse substances and structures. However, CD spectroscopy is inherently weak and conventionally associated with chiral sensing, thus constraining its range of applications. Here, we report a DNA-origami-empowered metasurface sensing platform through the collaborative effect of metasurfaces and DNA origami, enabling achiral/slightly chiral sensing with high sensitivity via the enhanced ΔCD. An anapole metasurface, boasting over 60 times the average optical chirality enhancement, was elaborately designed to synergize with reconfigurable DNA origami. We experimentally demonstrated the detection of achiral/slightly chiral DNA linker strands via the enhanced ΔCD of the proposed platform, whose sensitivity was a 10-fold enhancement compared with the platform without metasurfaces. Our work presents a high-sensitivity platform for achiral/slightly chiral sensing through chiral spectroscopy, expanding the capabilities of chiral spectroscopy and inspiring the integration of multifunctional artificial nanostructures across diverse domains.
摘要：
圆二色性(CD)光谱法已被广泛用于检测和区分不同物质和结构的手性。然而,CD光谱学本质上很弱，通常与手性传感相关，从而限制了其应用范围。这里,我们报告了一个DNA折纸授权的超表面传感平台，通过超表面和DNA折纸的协同作用，通过增强的ΔCD实现高灵敏度的非手性/轻微手性传感。一个足月超表面，拥有超过60倍的平均光学手性增强，经过精心设计，可以与可重构的DNA折纸进行协同作用。我们通过实验证明了通过所提出平台的增强的ΔCD检测非手性/轻度手性DNA接头链，与没有超表面的平台相比，其灵敏度提高了10倍。我们的工作提出了一个高灵敏度的平台，用于通过手性光谱进行非手性/轻微手性传感，扩大手性光谱学的能力，并激发多功能人造纳米结构在不同领域的整合。
