PDF(Pubmed)
Abstract：
UNASSIGNED: Depression is largely preventable, and strategies that can effectively suppress its development are imperative. We aimed to examine whether physical activity and sedentary behavior were associated with depression and explore the possible mediatory role of complete blood count in this association.
UNASSIGNED: In this cross-sectional study, data were integrated from the National Health and Nutrition Examination Study (2007-2018). Depression was defined using the Patient Health Questionnaire-9. The risk for depression, expressed as odds ratio (OR) and 95% confidence interval (CI), was quantified by survey-weighted logistic regression analyses.
UNASSIGNED: A total of 31,204 respondents were analyzed. Significance was identified for all, except walking or bicycling per week, types of physical activity, and sedentary behavior. Per 1 standard deviation (SD) increment in metabolic equivalent of task (MET) of weekly vigorous recreational physical activity was associated with 31.3% decreased depression risk (adjusted OR: 0.687, 95% CI: 0.5663-0.840). Per 1 SD increment in sitting time can increase depression risk by 22.4% (adjusted OR: 1.224, 95% CI: 1.131-1.325). In subsidiary analyses, the association with depression was reinforced in respondents aged ≤65 years and those overweight or obese. Mediation analyses revealed significant effects for red blood cell (RBC) on total MET (19.4%) and moderate work-related physical activity (MWPA) (22.0%), and for red cell distribution wide (RCDW) on vigorous work-related physical activity (17.7%), moderate work-related physical activity (13.1%), total MET (11.2%), and sitting time (16.4%) (p < 0.01).
UNASSIGNED: Our findings indicate that more physical activity and less sitting time were associated with a lower likelihood of having depression among US adults, and this association was probably mediated by RBC and RCDW.
UNASSIGNED: In this cross-sectional study, data were integrated from the National Health and Nutrition Examination Study (2007-2018). Depression was defined using the Patient Health Questionnaire-9. The risk for depression, expressed as odds ratio (OR) and 95% confidence interval (CI), was quantified by survey-weighted logistic regression analyses.
UNASSIGNED: A total of 31,204 respondents were analyzed. Significance was identified for all, except walking or bicycling per week, types of physical activity, and sedentary behavior. Per 1 standard deviation (SD) increment in metabolic equivalent of task (MET) of weekly vigorous recreational physical activity was associated with 31.3% decreased depression risk (adjusted OR: 0.687, 95% CI: 0.5663-0.840). Per 1 SD increment in sitting time can increase depression risk by 22.4% (adjusted OR: 1.224, 95% CI: 1.131-1.325). In subsidiary analyses, the association with depression was reinforced in respondents aged ≤65 years and those overweight or obese. Mediation analyses revealed significant effects for red blood cell (RBC) on total MET (19.4%) and moderate work-related physical activity (MWPA) (22.0%), and for red cell distribution wide (RCDW) on vigorous work-related physical activity (17.7%), moderate work-related physical activity (13.1%), total MET (11.2%), and sitting time (16.4%) (p < 0.01).
UNASSIGNED: Our findings indicate that more physical activity and less sitting time were associated with a lower likelihood of having depression among US adults, and this association was probably mediated by RBC and RCDW.
摘要：
■抑郁症在很大程度上是可以预防的，能够有效抑制其发展的战略势在必行。我们旨在研究身体活动和久坐行为是否与抑郁症有关，并探讨全血细胞计数在这种关联中的可能中介作用。
■在这项横断面研究中，数据来自国家健康和营养检查研究(2007-2018).使用患者健康问卷-9定义抑郁症。患抑郁症的风险,表示为优势比(OR)和95%置信区间(CI)，通过调查加权逻辑回归分析进行量化。
■共分析了31,204名受访者。对所有人都有意义，除了每周步行或骑自行车，身体活动的类型，和久坐的行为。每周进行剧烈的娱乐性体育活动的任务代谢当量（MET）每增加1个标准差（SD），抑郁风险降低31.3％（调整后的OR：0.687，95％CI：0.5663-0.840）。坐着时间每增加1SD可使抑郁风险增加22.4％（调整后OR：1.224，95％CI：1.131-1.325）。在子公司分析中，在年龄≤65岁和超重或肥胖的受访者中,与抑郁的关联得到加强.中介分析显示，红细胞(RBC)对总MET(19.4%)和中等工作相关体力活动(MWPA)(22.0%)有显著影响。以及与剧烈工作相关的体力活动的红细胞分布范围(RCDW)(17.7%)，适度的与工作相关的身体活动(13.1%)，总MET（11.2%），和久坐时间(16.4%)(p<0.01)。
■我们的研究结果表明，更多的体力活动和更少的坐着时间与美国成年人患抑郁症的可能性较低有关。这种关联可能是由RBC和RCDW介导的。
■在这项横断面研究中，数据来自国家健康和营养检查研究(2007-2018).使用患者健康问卷-9定义抑郁症。患抑郁症的风险,表示为优势比(OR)和95%置信区间(CI)，通过调查加权逻辑回归分析进行量化。
■共分析了31,204名受访者。对所有人都有意义，除了每周步行或骑自行车，身体活动的类型，和久坐的行为。每周进行剧烈的娱乐性体育活动的任务代谢当量（MET）每增加1个标准差（SD），抑郁风险降低31.3％（调整后的OR：0.687，95％CI：0.5663-0.840）。坐着时间每增加1SD可使抑郁风险增加22.4％（调整后OR：1.224，95％CI：1.131-1.325）。在子公司分析中，在年龄≤65岁和超重或肥胖的受访者中,与抑郁的关联得到加强.中介分析显示，红细胞(RBC)对总MET(19.4%)和中等工作相关体力活动(MWPA)(22.0%)有显著影响。以及与剧烈工作相关的体力活动的红细胞分布范围(RCDW)(17.7%)，适度的与工作相关的身体活动(13.1%)，总MET（11.2%），和久坐时间(16.4%)(p<0.01)。
■我们的研究结果表明，更多的体力活动和更少的坐着时间与美国成年人患抑郁症的可能性较低有关。这种关联可能是由RBC和RCDW介导的。
