PDF(Pubmed)
Abstract：
UNASSIGNED: Sleeve gastrectomy (SG) is currently the most frequently performed bariatric procedure in the world. However, the occurrence of gastroesophageal reflux disease (GERD) after SG remains controversial and questionable.
UNASSIGNED: To determine the occurrence of GERD after SG using a pH-monitoring study.
UNASSIGNED: This is a prospective study involving patients undergoing SG in one surgical centre. Inclusion criteria were eligibility for bariatric surgery, no symptoms of GERD, normal gastroscopy, and pH-monitoring before the surgery. Postoperative examinations were performed 6 months after surgery.
UNASSIGNED: A total of 38 patients were analysed in the study. The mean age was 44.9 years, and the mean preoperative BMI was 42.6 kg/m2. Before surgery, all patients had normal pH values. After surgery, mean acid exposure time (AET), number of refluxes, and DeMeester score increased statistically significantly (p < 0.001). 27 (71.1%) patients each had AET > 6%, but only 9 (23.7%) reported GERD symptoms and the need for PPIs. The correlation between AET and %TWL was moderate positive, and the correlation between DeMeester score and %TWL was low positive (p = 0.011, p = 0.014, respectively).
UNASSIGNED: GERD after SG seems to be a significant problem. More than two-thirds of patients had de novo GERD after SG in pH-monitoring, but only one-quarter of them required PPIs.
UNASSIGNED: To determine the occurrence of GERD after SG using a pH-monitoring study.
UNASSIGNED: This is a prospective study involving patients undergoing SG in one surgical centre. Inclusion criteria were eligibility for bariatric surgery, no symptoms of GERD, normal gastroscopy, and pH-monitoring before the surgery. Postoperative examinations were performed 6 months after surgery.
UNASSIGNED: A total of 38 patients were analysed in the study. The mean age was 44.9 years, and the mean preoperative BMI was 42.6 kg/m2. Before surgery, all patients had normal pH values. After surgery, mean acid exposure time (AET), number of refluxes, and DeMeester score increased statistically significantly (p < 0.001). 27 (71.1%) patients each had AET > 6%, but only 9 (23.7%) reported GERD symptoms and the need for PPIs. The correlation between AET and %TWL was moderate positive, and the correlation between DeMeester score and %TWL was low positive (p = 0.011, p = 0.014, respectively).
UNASSIGNED: GERD after SG seems to be a significant problem. More than two-thirds of patients had de novo GERD after SG in pH-monitoring, but only one-quarter of them required PPIs.
摘要：
■袖状胃切除术（SG）是目前世界上最常用的减肥手术。然而,SG后胃食管反流病(GERD)的发生仍存在争议和疑问.
■使用pH监测研究确定SG后GERD的发生。
■这是一项前瞻性研究，涉及在一个外科中心接受SG的患者。纳入标准是减肥手术的资格，没有GERD的症状,正常胃镜检查，和手术前的pH监测。术后6个月进行术后检查。
■本研究共分析了38例患者。平均年龄是44.9岁,术前平均BMI为42.6kg/m2。手术前,所有患者的pH值正常.手术后,平均酸暴露时间（AET），回流次数,和DeMeester评分在统计学上显著增加(p<0.001)。27例(71.1%)患者AET>6%，但只有9例(23.7%)报告了GERD症状和需要PPI。AET与%TWL呈中度正相关,DeMeester评分与％TWL之间的相关性较低（分别为p=0.011，p=0.014）。
■SG后的GERD似乎是一个重大问题。在pH监测中，超过三分之二的患者在SG后出现从头GERD，但其中只有四分之一需要PPI。
■使用pH监测研究确定SG后GERD的发生。
■这是一项前瞻性研究，涉及在一个外科中心接受SG的患者。纳入标准是减肥手术的资格，没有GERD的症状,正常胃镜检查，和手术前的pH监测。术后6个月进行术后检查。
■本研究共分析了38例患者。平均年龄是44.9岁,术前平均BMI为42.6kg/m2。手术前,所有患者的pH值正常.手术后,平均酸暴露时间（AET），回流次数,和DeMeester评分在统计学上显著增加(p<0.001)。27例(71.1%)患者AET>6%，但只有9例(23.7%)报告了GERD症状和需要PPI。AET与%TWL呈中度正相关,DeMeester评分与％TWL之间的相关性较低（分别为p=0.011，p=0.014）。
■SG后的GERD似乎是一个重大问题。在pH监测中，超过三分之二的患者在SG后出现从头GERD，但其中只有四分之一需要PPI。
