Abstract：
OBJECTIVE: To evaluate whether seasonal changes influence fluctuations in serum Krebs von den Lungen-6 (KL-6) levels in systemic sclerosis-related interstitial lung disease (SSc-ILD).
METHODS: Summer was defined as the period between July and September, and winter as between December and February. The study was conducted between 2015 and 2016, with a focus on these two seasons. A diagnosis of ILD and ILD progression overtime were evaluated using chest computed tomography. Among patients with SSc-ILD, those with data on serum KL-6 and lactate dehydrogenase (LDH) levels in the 2015 winter, 2015 summer, and 2016 winter seasons were included. Patients with comorbidities that could affect serum KL-6 levels were excluded.
RESULTS: Of 60 patients with SSc-ILD, 52 (86.7%) had stable ILD, 5 (8.3%) had worsened ILD, and 3 (5.0%) had improved ILD. Serum KL-6 levels were significantly higher during the winter than those during the summer (2015 winter vs. 2015 summer: 649 U/mL vs. 585 U/mL, p < .0001; 2016 winter vs. 2015 summer: 690 U/mL vs. 585 U/mL, p < .0001). No significant differences were observed between the winters of 2015 and 2016 (649 U/mL vs. 690 U/mL, p = .78). However, serum LDH levels did not exhibit seasonal fluctuations (2015 winter vs. 2015 summer: 203 U/L vs. 199 U/L, p = .3; 2016 winter vs. 2015 summer: 201 U/L vs. 199 U/L, p = .6; 2015 winter vs. 2016 winter: 203 U/L vs. 201 U/L, p = .24).
CONCLUSIONS: Seasonal fluctuations in serum KL-6 levels were observed in patients with SSc-ILD.
METHODS: Summer was defined as the period between July and September, and winter as between December and February. The study was conducted between 2015 and 2016, with a focus on these two seasons. A diagnosis of ILD and ILD progression overtime were evaluated using chest computed tomography. Among patients with SSc-ILD, those with data on serum KL-6 and lactate dehydrogenase (LDH) levels in the 2015 winter, 2015 summer, and 2016 winter seasons were included. Patients with comorbidities that could affect serum KL-6 levels were excluded.
RESULTS: Of 60 patients with SSc-ILD, 52 (86.7%) had stable ILD, 5 (8.3%) had worsened ILD, and 3 (5.0%) had improved ILD. Serum KL-6 levels were significantly higher during the winter than those during the summer (2015 winter vs. 2015 summer: 649 U/mL vs. 585 U/mL, p < .0001; 2016 winter vs. 2015 summer: 690 U/mL vs. 585 U/mL, p < .0001). No significant differences were observed between the winters of 2015 and 2016 (649 U/mL vs. 690 U/mL, p = .78). However, serum LDH levels did not exhibit seasonal fluctuations (2015 winter vs. 2015 summer: 203 U/L vs. 199 U/L, p = .3; 2016 winter vs. 2015 summer: 201 U/L vs. 199 U/L, p = .6; 2015 winter vs. 2016 winter: 203 U/L vs. 201 U/L, p = .24).
CONCLUSIONS: Seasonal fluctuations in serum KL-6 levels were observed in patients with SSc-ILD.
摘要：
目的：评估季节性变化是否影响系统性硬化症相关性间质性肺病（SSc-ILD）患者血清KrebsvondenLungen-6（KL-6）水平的波动。
方法：夏季定义为7月至9月之间的时期，12月到2月之间的冬天。这项研究是在2015年至2016年之间进行的，重点是这两个季节。使用胸部计算机断层扫描评估ILD和ILD随时间推移进展的诊断。在SSc-ILD患者中，那些有2015年冬季血清KL-6和乳酸脱氢酶（LDH）水平数据的人，2015年夏天,包括2016年冬季。排除可能影响血清KL-6水平的合并症患者。
结果：在60例SSc-ILD患者中，52(86.7%)有稳定的ILD，5（8.3%）ILD恶化，3例（5.0%）ILD改善。血清KL-6水平在冬季明显高于夏季（2015年冬季与2015年夏季：649U/mLvs.585U/mL,p<.0001;2016年冬季vs.2015年夏季：690U/mLvs.585U/mL,p<.0001)。2015年和2016年冬季之间没有观察到显著差异(649U/mL与690U/mL,p=.78）。然而,血清LDH水平没有出现季节性波动(2015年冬季与2015年夏季：203U/Lvs.199U/L,p=.3；2016年冬季vs.2015年夏季：201U/Lvs.199U/L,p=.6；2015年冬季与2016年冬季：203U/Lvs.201U/L,p=.24）。
结论：SSc-ILD患者血清KL-6水平呈季节性波动。
方法：夏季定义为7月至9月之间的时期，12月到2月之间的冬天。这项研究是在2015年至2016年之间进行的，重点是这两个季节。使用胸部计算机断层扫描评估ILD和ILD随时间推移进展的诊断。在SSc-ILD患者中，那些有2015年冬季血清KL-6和乳酸脱氢酶（LDH）水平数据的人，2015年夏天,包括2016年冬季。排除可能影响血清KL-6水平的合并症患者。
结果：在60例SSc-ILD患者中，52(86.7%)有稳定的ILD，5（8.3%）ILD恶化，3例（5.0%）ILD改善。血清KL-6水平在冬季明显高于夏季（2015年冬季与2015年夏季：649U/mLvs.585U/mL,p<.0001;2016年冬季vs.2015年夏季：690U/mLvs.585U/mL,p<.0001)。2015年和2016年冬季之间没有观察到显著差异(649U/mL与690U/mL,p=.78）。然而,血清LDH水平没有出现季节性波动(2015年冬季与2015年夏季：203U/Lvs.199U/L,p=.3；2016年冬季vs.2015年夏季：201U/Lvs.199U/L,p=.6；2015年冬季与2016年冬季：203U/Lvs.201U/L,p=.24）。
结论：SSc-ILD患者血清KL-6水平呈季节性波动。
