设计,新型非酮内酯的合成和结构 - 活性关系 : 9 - 肟克拉霉素在 3 - OH 上具有 7 至 13 个原子长度的二胺接头。
关键词: Ciprofloxacin Erythromycin Macrolide Quinolone Resistant bacteria Ribosome
Mesh : Structure-Activity Relationship Clarithromycin / pharmacology chemistry chemical synthesis Drug Design Anti-Bacterial Agents / pharmacology chemical synthesis chemistry Microbial Sensitivity Tests Molecular Structure Diamines / chemistry pharmacology chemical synthesis Haemophilus influenzae / drug effects Oximes / chemistry pharmacology chemical synthesis Dose-Response Relationship, Drug Humans Animals Streptococcus pyogenes / drug effects Drug Resistance, Bacterial / drug effects
来 源: DOI:10.1016/j.ejmech.2024.116630