PDF(Pubmed)
Abstract：
Influenza viruses are responsible for a high number of infections and hospitalizations every year. In this study, we aimed to identify clinical and host-specific factors that influence the duration of hospitalization and the progression to acute respiratory failure (ARF) in influenza. We performed an analysis of data from a prospective active influenza surveillance study that was conducted over five seasons (2018/19 to 2022/23). A total of 1402 patients with influenza were included in the analysis, the majority of which (64.5%) were children (under 18 years), and 9.1% were elderly. At least one chronic condition was present in 29.2% of patients, and 9.9% of patients developed ARF. The median hospital stay was 4 days (IQR: 3, 6 days). The most important predictors of prolonged hospital stay and development of ARF were extremes of age (infants and elderly), presence of chronic diseases, particularly the cumulus of at least 3 chronic diseases, and late presentation to hospital. Among the chronic diseases, chronic obstructive pulmonary disease, cardiovascular disease, cancer, diabetes, obesity, and chronic kidney disease were strongly associated with a longer duration of hospitalization and occurrence of ARF. In this context, interventions aimed at chronic disease management, promoting influenza vaccination, and improving awareness and access to health services may contribute to reducing the impact of influenza not only in Romania but globally. In addition, continued monitoring of the circulation of influenza viruses is essential to limit their spread among vulnerable populations.
摘要：
流感病毒每年导致大量感染和住院。在这项研究中,我们旨在确定影响流感患者住院时间和急性呼吸衰竭(ARF)进展的临床和宿主特异性因素.我们对为期五个季节（2018/19至2022/23）的前瞻性主动流感监测研究的数据进行了分析。共纳入1402例流感患者的分析，其中大多数(64.5%)是儿童(18岁以下)，老年人占9.1%。29.2％的患者至少有一种慢性疾病，9.9%的患者发生ARF。中位住院时间为4天（IQR：3、6天）。住院时间延长和ARF发展的最重要的预测因素是极端年龄（婴儿和老人），慢性疾病的存在，特别是至少3种慢性疾病的积云，迟交医院。在慢性病中，慢性阻塞性肺疾病,心血管疾病,癌症,糖尿病,肥胖，慢性肾脏病与住院时间延长和ARF发生密切相关.在这种情况下，旨在慢性病管理的干预措施，推广流感疫苗接种,和提高认识和获得卫生服务可能有助于减少流感的影响，不仅在罗马尼亚，而且在全球。此外,继续监测流感病毒的传播对限制其在弱势群体中的传播至关重要。
