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Abstract：
BACKGROUND: Preserved ratio impaired spirometry (PRISm) is a type of abnormal lung function. PRISm and mortality have been explored in several studies, but a comprehensive evaluation of the associations is limited. The current study aims to conduct a systematic review and meta-analysis in order to investigate the mortality and cardiovascular diseases in patients with PRISm.
METHODS: PubMed, Embase, and Web of Science databases, as well as gray literature sources, were searched for relevant studies published up to 7 September 2023 without language restrictions. This review included all published observational cohort studies that investigated the association of PRISm with mortality in the general population, as well as subgroup analyses in smokers and pre-bronchodilation spirometry studies. The outcomes of interest were all-cause mortality, cardiovascular mortality, and respiratory-related mortality. The Newcastle-Ottawa scale assessed study quality. Sensitivity and subgroup analyses explored heterogeneity and robustness. Publication bias was assessed with Egger\'s and Begg\'s tests.
RESULTS: Overall, eight studies were included in this meta-analysis. The pooled HR was 1.60 (95% CI, 1.48-1.74) for all-cause mortality, 1.68 (95% CI, 1.46-1.94) for CVD mortality, and 3.09 (95% CI, 1.42-6.71) for respiratory-related mortality in PRISm group compared to normal group. In the subgroup analysis, participants with PRISm had a higher effect (HR, 2.11; 95% CI, 1.74-2.54) on all-cause mortality among smokers relative to participants with normal spirometry. Furthermore, the association between PRISm and mortality risk was consistent across several sensitivity analyses.
CONCLUSIONS: People with PRISm were associated with an increased risk of all-cause mortality, CVD mortality, and respiratory-related mortality as compared to those with normal lung function in the general population.
BACKGROUND: PROSPERO CRD42023426872.
METHODS: PubMed, Embase, and Web of Science databases, as well as gray literature sources, were searched for relevant studies published up to 7 September 2023 without language restrictions. This review included all published observational cohort studies that investigated the association of PRISm with mortality in the general population, as well as subgroup analyses in smokers and pre-bronchodilation spirometry studies. The outcomes of interest were all-cause mortality, cardiovascular mortality, and respiratory-related mortality. The Newcastle-Ottawa scale assessed study quality. Sensitivity and subgroup analyses explored heterogeneity and robustness. Publication bias was assessed with Egger\'s and Begg\'s tests.
RESULTS: Overall, eight studies were included in this meta-analysis. The pooled HR was 1.60 (95% CI, 1.48-1.74) for all-cause mortality, 1.68 (95% CI, 1.46-1.94) for CVD mortality, and 3.09 (95% CI, 1.42-6.71) for respiratory-related mortality in PRISm group compared to normal group. In the subgroup analysis, participants with PRISm had a higher effect (HR, 2.11; 95% CI, 1.74-2.54) on all-cause mortality among smokers relative to participants with normal spirometry. Furthermore, the association between PRISm and mortality risk was consistent across several sensitivity analyses.
CONCLUSIONS: People with PRISm were associated with an increased risk of all-cause mortality, CVD mortality, and respiratory-related mortality as compared to those with normal lung function in the general population.
BACKGROUND: PROSPERO CRD42023426872.
摘要：
背景：保留比率肺活量测定（PRISm）是一种异常的肺功能。PRISm和死亡率已经在一些研究中进行了探讨，但是对协会的综合评估是有限的。本研究旨在进行系统评价和荟萃分析，以调查PRISm患者的死亡率和心血管疾病。
方法：PubMed，Embase,和WebofScience数据库,以及灰色文献来源，搜索了截至2023年9月7日发表的相关研究，没有语言限制。这篇综述包括所有已发表的观察性队列研究，这些研究调查了PRISm与普通人群死亡率的关系。以及吸烟者的亚组分析和支气管扩张前肺活量测定研究。感兴趣的结果是全因死亡率，心血管死亡率，与呼吸有关的死亡率。纽卡斯尔-渥太华量表评估研究质量。敏感性和亚组分析探讨了异质性和稳健性。发表偏倚用Egger和Begg测试进行评估。
结果：总体而言，本荟萃分析纳入了8项研究.全因死亡率的合并HR为1.60（95%CI，1.48-1.74），CVD死亡率为1.68（95%CI，1.46-1.94），与正常组相比，PRISm组的呼吸相关死亡率为3.09（95％CI，1.42-6.71）。在亚组分析中，PRISm的参与者有更高的效果(HR，2.11;95％CI，1.74-2.54）吸烟者相对于肺活量正常的参与者的全因死亡率。此外，在多项敏感性分析中,PRISm与死亡风险之间的关联是一致的.
结论：PRISm患者与全因死亡风险增加相关，CVD死亡率，与普通人群肺功能正常的人群相比，与呼吸相关的死亡率。
背景：PROSPEROCRD42023426872。
方法：PubMed，Embase,和WebofScience数据库,以及灰色文献来源，搜索了截至2023年9月7日发表的相关研究，没有语言限制。这篇综述包括所有已发表的观察性队列研究，这些研究调查了PRISm与普通人群死亡率的关系。以及吸烟者的亚组分析和支气管扩张前肺活量测定研究。感兴趣的结果是全因死亡率，心血管死亡率，与呼吸有关的死亡率。纽卡斯尔-渥太华量表评估研究质量。敏感性和亚组分析探讨了异质性和稳健性。发表偏倚用Egger和Begg测试进行评估。
结果：总体而言，本荟萃分析纳入了8项研究.全因死亡率的合并HR为1.60（95%CI，1.48-1.74），CVD死亡率为1.68（95%CI，1.46-1.94），与正常组相比，PRISm组的呼吸相关死亡率为3.09（95％CI，1.42-6.71）。在亚组分析中，PRISm的参与者有更高的效果(HR，2.11;95％CI，1.74-2.54）吸烟者相对于肺活量正常的参与者的全因死亡率。此外，在多项敏感性分析中,PRISm与死亡风险之间的关联是一致的.
结论：PRISm患者与全因死亡风险增加相关，CVD死亡率，与普通人群肺功能正常的人群相比，与呼吸相关的死亡率。
背景：PROSPEROCRD42023426872。
