METHODS: This cross-sectional study analyzed neurophysiological, clinical, and demographical data from 102 stroke patients from the DEFINE cohort. We searched for correlations of EEG and TMS measurements combined to build a prediction model for upper limb motor functionality, assessed by five outcomes, across five assessments: Fugl-Meyer Assessment (FMA), Handgrip Strength Test (HST), Finger Tapping Test (FTT), Nine-Hole Peg Test (9HPT), and Pinch Strength Test (PST).
RESULTS: Our multivariate models agreed on a specific neural signature: higher EEG Theta/Alpha ratio in the frontal region of the lesioned hemisphere is associated with poorer motor outcomes, while increased MEP amplitude in the non-lesioned hemisphere correlates with improved motor function. These relationships are held across all five motor assessments, suggesting the potential of these neurophysiological measures as recovery biomarkers.
CONCLUSIONS: Our findings indicate a potential neural signature of brain compensation in which lower frequencies of EEG power are increased in the lesioned hemisphere, and lower corticospinal excitability is also increased in the non-lesioned hemisphere. We discuss the meaning of these findings in the context of motor recovery in stroke.
方法:这项横断面研究分析了神经生理学,临床,和来自DEFINE队列的102名卒中患者的人口统计学数据。我们搜索EEG和TMS测量值的相关性,以建立上肢运动功能的预测模型,由五个结果评估,跨越五项评估:Fugl-Meyer评估(FMA),手柄强度测试(HST),手指敲击测试(FTT),九孔钉试验(9HPT),和夹头强度测试(PST)。
结果:我们的多变量模型在特定的神经特征上达成一致:病变半球额叶区域较高的EEGTheta/Alpha比率与较差的运动结果相关,而无病变半球MEP振幅的增加与运动功能的改善相关。这些关系在所有五项运动评估中都有,提示这些神经生理学措施作为恢复生物标志物的潜力。
结论:我们的发现表明大脑代偿的潜在神经特征,在病变半球中,较低的EEG功率频率增加,和较低的皮质脊髓兴奋性也在未损伤的半球增加。我们在中风运动恢复的背景下讨论这些发现的意义。