PDF(Pubmed)
Abstract：
BACKGROUND: Alcohol use disorder (AUD) courses with inflammation and cognitive decline. Apolipoproteins have emerged as novel target compounds related to inflammatory processes and cognition.
METHODS: A cross-sectional study was performed on abstinent AUD patients with at least 1 month of abstinence (n = 33; 72.7% men) and healthy controls (n = 34; 47.1% men). A battery of plasma apolipoproteins (APOAI, APOAII, APOB, APOCII, APOE, APOJ, and APOM), plasma inflammatory markers (LPS, LBP), and their influence on cognition and presence of the disorder were investigated.
RESULTS: Higher levels of plasma APOAI, APOB, APOE, and APOJ, as well as the proinflammatory LPS, were observed in the AUD group, irrespective of sex, whereas APOM levels were lower vs controls. Hierarchical logistic regression analyses, adjusting for covariates (age, sex, education), associated APOM with the absence of cognitive impairment in AUD and identified APOAI and APOM as strong predictors of the presence or absence of the disorder, respectively. APOAI and APOM did not correlate with alcohol abuse variables or liver status markers, but they showed an opposite profile in their associations with LPS (positive for APOAI; negative for APOM) and cognition (negative for APOAI; positive for APOM) in the entire sample.
CONCLUSIONS: The HDL constituents APOAI and APOM were differentially regulated in the plasma of AUD patients compared with controls, playing divergent roles in the disorder identification and associations with inflammation and cognitive decline.
METHODS: A cross-sectional study was performed on abstinent AUD patients with at least 1 month of abstinence (n = 33; 72.7% men) and healthy controls (n = 34; 47.1% men). A battery of plasma apolipoproteins (APOAI, APOAII, APOB, APOCII, APOE, APOJ, and APOM), plasma inflammatory markers (LPS, LBP), and their influence on cognition and presence of the disorder were investigated.
RESULTS: Higher levels of plasma APOAI, APOB, APOE, and APOJ, as well as the proinflammatory LPS, were observed in the AUD group, irrespective of sex, whereas APOM levels were lower vs controls. Hierarchical logistic regression analyses, adjusting for covariates (age, sex, education), associated APOM with the absence of cognitive impairment in AUD and identified APOAI and APOM as strong predictors of the presence or absence of the disorder, respectively. APOAI and APOM did not correlate with alcohol abuse variables or liver status markers, but they showed an opposite profile in their associations with LPS (positive for APOAI; negative for APOM) and cognition (negative for APOAI; positive for APOM) in the entire sample.
CONCLUSIONS: The HDL constituents APOAI and APOM were differentially regulated in the plasma of AUD patients compared with controls, playing divergent roles in the disorder identification and associations with inflammation and cognitive decline.
摘要：
背景：酒精使用障碍（AUD）伴随炎症和认知功能下降的过程。载脂蛋白已成为与炎症过程和认知相关的新型靶化合物。
方法：对禁欲至少一个月的禁欲AUD患者（n=33；72.7%男性）和健康对照（n=34；47.1%男性）进行了横断面研究。一系列血浆载脂蛋白(APOAI，APOAII,APOB,APOCII,APOE,APOJ和APOM），血浆炎症标志物(LPS，LBP),并调查了它们对认知和疾病存在的影响。
结果：血浆APOAI水平较高，APOB,APOE和APOJ,以及促炎LPS，在AUD组中观察到，不论性别,而APOM水平低于对照组。分层逻辑回归分析，调整协变量(年龄，性别,education),APOM与AUD无认知障碍相关，并确定APOAI和APOM是该疾病存在或不存在的有力预测因子，分别。APOAI和APOM与酒精滥用变量或肝脏状态标志物无关，但它们与LPS（APOAI阳性；APOM阴性）和认知（APOAI阴性；APOM阳性）的相关性却相反。
结论：与对照组相比，AUD受试者血浆中HDL成分APOAI和APOM的调节差异，在疾病识别以及与炎症和认知能力下降的关联中起着不同的作用。
方法：对禁欲至少一个月的禁欲AUD患者（n=33；72.7%男性）和健康对照（n=34；47.1%男性）进行了横断面研究。一系列血浆载脂蛋白(APOAI，APOAII,APOB,APOCII,APOE,APOJ和APOM），血浆炎症标志物(LPS，LBP),并调查了它们对认知和疾病存在的影响。
结果：血浆APOAI水平较高，APOB,APOE和APOJ,以及促炎LPS，在AUD组中观察到，不论性别,而APOM水平低于对照组。分层逻辑回归分析，调整协变量(年龄，性别,education),APOM与AUD无认知障碍相关，并确定APOAI和APOM是该疾病存在或不存在的有力预测因子，分别。APOAI和APOM与酒精滥用变量或肝脏状态标志物无关，但它们与LPS（APOAI阳性；APOM阴性）和认知（APOAI阴性；APOM阳性）的相关性却相反。
结论：与对照组相比，AUD受试者血浆中HDL成分APOAI和APOM的调节差异，在疾病识别以及与炎症和认知能力下降的关联中起着不同的作用。
