PDF(Pubmed)
Abstract：
BACKGROUND: Chronic gastritis caused by Helicobacter pylori (Hp) infection is a common gastrointestinal disorder. Despite the high prevalence of Hp infection and chronic gastritis in the Tibetan Plateau, there is a lack of studies elucidating the influence of plateau hypoxia on Hp-induced gastritis. This study aimed to investigate the impact of high-altitude hypoxia on Hp-induced gastritis, particularly focusing on pathological manifestations and inflammatory responses.
METHODS: This study was conducted from July 2023 to March 2024 at the Department of Gastroenterology, Affiliated Hospital of Qinghai University. Ninety patients diagnosed with chronic gastritis were enrolled in the study and divided into four groups based on their residential altitude and Hp infection status. Data on endoscopic and pathological characteristics were collected, along with serum oxidative stress and inflammatory markers.
RESULTS: Patients with Hp gastritis exhibit distinctive features in the gastric mucosa, including diffuse erythema, enlarged folds, and white turbid mucus during endoscopy. Notably, individuals with Hp gastritis at high altitudes show a higher prevalence of diffuse erythema and enlarged folds. Pathological analysis reveals that these patients have elevated gastric mucosal inflammation scores and increased chronic and active inflammation. Furthermore, individuals with Hp gastritis at high altitudes demonstrate elevated levels of serum TNF-α, IL-1β, IL-6, and MDA, as well as reduced serum SOD and GSH-Px activities.
CONCLUSIONS: High-altitude hypoxia may exacerbate gastric mucosal damage by enhancing oxidative stress and inflammatory response induced by Hp infection.
METHODS: This study was conducted from July 2023 to March 2024 at the Department of Gastroenterology, Affiliated Hospital of Qinghai University. Ninety patients diagnosed with chronic gastritis were enrolled in the study and divided into four groups based on their residential altitude and Hp infection status. Data on endoscopic and pathological characteristics were collected, along with serum oxidative stress and inflammatory markers.
RESULTS: Patients with Hp gastritis exhibit distinctive features in the gastric mucosa, including diffuse erythema, enlarged folds, and white turbid mucus during endoscopy. Notably, individuals with Hp gastritis at high altitudes show a higher prevalence of diffuse erythema and enlarged folds. Pathological analysis reveals that these patients have elevated gastric mucosal inflammation scores and increased chronic and active inflammation. Furthermore, individuals with Hp gastritis at high altitudes demonstrate elevated levels of serum TNF-α, IL-1β, IL-6, and MDA, as well as reduced serum SOD and GSH-Px activities.
CONCLUSIONS: High-altitude hypoxia may exacerbate gastric mucosal damage by enhancing oxidative stress and inflammatory response induced by Hp infection.
摘要：
背景：幽门螺杆菌（Hp）感染引起的慢性胃炎是一种常见的胃肠道疾病。尽管青藏高原Hp感染和慢性胃炎的患病率很高,缺乏阐明高原低氧对Hp诱导的胃炎的影响的研究。本研究旨在探讨高原低氧对Hp所致胃炎的影响,特别关注病理表现和炎症反应。
方法：这项研究于2023年7月至2024年3月在消化内科进行，青海大学附属医院.90例诊断为慢性胃炎的患者被纳入研究，并根据其居住海拔和Hp感染状况分为四组。收集内镜和病理特征的数据，以及血清氧化应激和炎症标志物。
结果：Hp胃炎患者在胃粘膜表现出独特的特征，包括弥漫性红斑,扩大的褶皱，内窥镜检查时出现白色混浊粘液。值得注意的是,在高海拔地区患有Hp胃炎的个体表现出更高的弥漫性红斑和扩大的褶皱患病率。病理分析表明，这些患者的胃粘膜炎症评分升高，慢性和活动性炎症增加。此外，高海拔地区Hp胃炎患者血清TNF-α水平升高，IL-1β,IL-6和MDA,以及降低血清SOD和GSH-Px活性。
结论：高原缺氧可能通过增强Hp感染引起的氧化应激和炎症反应而加剧胃黏膜损伤。
方法：这项研究于2023年7月至2024年3月在消化内科进行，青海大学附属医院.90例诊断为慢性胃炎的患者被纳入研究，并根据其居住海拔和Hp感染状况分为四组。收集内镜和病理特征的数据，以及血清氧化应激和炎症标志物。
结果：Hp胃炎患者在胃粘膜表现出独特的特征，包括弥漫性红斑,扩大的褶皱，内窥镜检查时出现白色混浊粘液。值得注意的是,在高海拔地区患有Hp胃炎的个体表现出更高的弥漫性红斑和扩大的褶皱患病率。病理分析表明，这些患者的胃粘膜炎症评分升高，慢性和活动性炎症增加。此外，高海拔地区Hp胃炎患者血清TNF-α水平升高，IL-1β,IL-6和MDA,以及降低血清SOD和GSH-Px活性。
结论：高原缺氧可能通过增强Hp感染引起的氧化应激和炎症反应而加剧胃黏膜损伤。
