PDF(Pubmed)
Abstract：
BACKGROUND: Redondoviridae is a newly discovered virus family linked to oral and respiratory conditions in people, while there is still debate about whether it is also coinfected with other respiratory viruses. This study aimed to determine the frequency of Redondovirus (ReDoV) in nasopharyngeal samples and to investigate any possible links to SARS-CoV-2 infections.
METHODS: A polymerase chain reaction (PCR) test was conducted on 731 nasopharyngeal samples from individuals referred to medical centers in Tehran, Iran, for SARS-CoV-2 testing to investigate the prevalence of ReDoV. An oral interview was performed to complete information on dental issues and the individuals\' demographics, symptoms, and vaccination history.
RESULTS: The prevalence of ReDoV was 25.99%, and 15.26% had a coinfection with SARS-CoV-2. No notable correlation was found regarding ReDoVs and SARS-CoV-2 infections (p > 0.05). Women had a higher ReDoV positivity rate of 18.47% compared to men at 7.52% (p = 0.12), and there was no significant correlation between age groups and ReDoV presence. Nonetheless, a significant association was noted between ReDoVs and dental/gum issues (p < 0.0001, OR: 13.0326). A phylogenetic analysis showed that ReDoVs originated from various human-related clusters.
CONCLUSIONS: These results highlight the potential for detecting ReDoVs in nasopharyngeal samples of people with gum or dental issues. Additionally, conducting more ReDoV epidemiological research and proposing oral health as a possible marker for ReDoV infections is important.
METHODS: A polymerase chain reaction (PCR) test was conducted on 731 nasopharyngeal samples from individuals referred to medical centers in Tehran, Iran, for SARS-CoV-2 testing to investigate the prevalence of ReDoV. An oral interview was performed to complete information on dental issues and the individuals\' demographics, symptoms, and vaccination history.
RESULTS: The prevalence of ReDoV was 25.99%, and 15.26% had a coinfection with SARS-CoV-2. No notable correlation was found regarding ReDoVs and SARS-CoV-2 infections (p > 0.05). Women had a higher ReDoV positivity rate of 18.47% compared to men at 7.52% (p = 0.12), and there was no significant correlation between age groups and ReDoV presence. Nonetheless, a significant association was noted between ReDoVs and dental/gum issues (p < 0.0001, OR: 13.0326). A phylogenetic analysis showed that ReDoVs originated from various human-related clusters.
CONCLUSIONS: These results highlight the potential for detecting ReDoVs in nasopharyngeal samples of people with gum or dental issues. Additionally, conducting more ReDoV epidemiological research and proposing oral health as a possible marker for ReDoV infections is important.
摘要：
背景：Redondoviridae是一种新发现的病毒家族，与人的口腔和呼吸道疾病有关，虽然它是否也与其他呼吸道病毒共感染仍存在争议。这项研究旨在确定鼻咽样本中Redondovirus（ReDoV）的频率，并调查与SARS-CoV-2感染的任何可能联系。
方法：对来自德黑兰医疗中心的731个个体的鼻咽样本进行了聚合酶链反应（PCR）测试，伊朗,进行SARS-CoV-2检测，以调查ReDoV的流行情况。进行了口头访谈，以完成有关牙科问题和个人人口统计的信息，症状,疫苗接种史。
结果：ReDoV的患病率为25.99%，15.26%的人与SARS-CoV-2合并感染。ReDoV与SARS-CoV-2感染无显著相关性(p>0.05)。女性的ReDoV阳性率较高，为18.47％，男性为7.52％（p=0.12），各年龄组与ReDoV的存在无显著相关性。尽管如此，ReDoV与牙齿/牙龈问题之间存在显著关联(p<0.0001,OR:13.0326).系统发育分析表明，ReDoV起源于各种与人类相关的簇。
结论：这些结果强调了在有牙龈或牙齿问题的人的鼻咽样本中检测ReDoV的潜力。此外,进行更多的ReDoV流行病学研究并提出口腔健康作为ReDoV感染的可能标志是重要的。
方法：对来自德黑兰医疗中心的731个个体的鼻咽样本进行了聚合酶链反应（PCR）测试，伊朗,进行SARS-CoV-2检测，以调查ReDoV的流行情况。进行了口头访谈，以完成有关牙科问题和个人人口统计的信息，症状,疫苗接种史。
结果：ReDoV的患病率为25.99%，15.26%的人与SARS-CoV-2合并感染。ReDoV与SARS-CoV-2感染无显著相关性(p>0.05)。女性的ReDoV阳性率较高，为18.47％，男性为7.52％（p=0.12），各年龄组与ReDoV的存在无显著相关性。尽管如此，ReDoV与牙齿/牙龈问题之间存在显著关联(p<0.0001,OR:13.0326).系统发育分析表明，ReDoV起源于各种与人类相关的簇。
结论：这些结果强调了在有牙龈或牙齿问题的人的鼻咽样本中检测ReDoV的潜力。此外,进行更多的ReDoV流行病学研究并提出口腔健康作为ReDoV感染的可能标志是重要的。
