Abstract：
With fungal diseases posing a major threat to agricultural production, the application of fungicides to control related diseases is often considered necessary to ensure the world\'s food supply. The search for new bioactive agents has long been a priority in crop protection due to the continuous development of resistance against currently used types of active compounds. Heterocyclic compounds are an inseparable part of the core structures of numerous lead compounds, these rings constitute pharmacophores of a significant number of fungicides developed over the past decade by agrochemists. Among heterocycles, nitrogen-based compounds play an essential role. To date, diazole (imidazole and pyrazole) and diazine (pyrimidine, pyridazine, and pyrazine) derivatives make up an important series of synthetic fungicides. In recent years, many reports have been published on the design, synthesis, and study of the fungicidal activity of these scaffolds, but there was a lack of a comprehensive classified review on nitrogen-containing scaffolds. Regarding this issue, here we have reviewed the published articles on the fungicidal activity of the diazole and diazine families. In current review, we have classified the molecules synthesized so far based on the size of the ring.
摘要：
真菌病害对农业生产构成重大威胁,使用杀菌剂来控制相关疾病通常被认为是确保世界粮食供应所必需的。由于对目前使用的活性化合物类型的抗性的不断发展,寻找新的生物活性剂长期以来一直是作物保护中的优先事项。杂环化合物是众多先导化合物核心结构不可分割的一部分,这些环构成了农业化学家在过去十年中开发的大量杀真菌剂的药效团。在杂环中，氮基化合物起着至关重要的作用。迄今为止,二唑（咪唑和吡唑）和二嗪（嘧啶，吖嗪,和吡嗪）衍生物构成了一系列重要的合成杀菌剂。近年来,已经发表了许多关于设计的报告，合成，并研究这些支架的杀菌活性，但是缺乏对含氮支架的全面分类审查。关于这个问题,在这里，我们回顾了有关二唑和二嗪家族的杀菌活性的已发表的文章。在目前的审查中，到目前为止，我们已经根据环的大小对合成的分子进行了分类。
