PDF(Pubmed)
Abstract：
UNASSIGNED: The incidence of early-onset colorectal cancer (EOCRC) is increasing globally. This study aims to describe the temporal trends of incidence and explore related risk exposures in early-life at the country level based on the GBD 2019.
UNASSIGNED: Data on the incidence and attributable risk factors of EOCRC were obtained from the GBD 2019. Temporal trends of age-standardized incidence were evaluated by average annual percentage change (AAPC). Early-life exposures were indicated as summary exposure values (SEV) of selected factors, SDI and GDP per capita in previous decades and at ages 0-4, 5-9, 10-14 and 15-19 years. Weighted linear or non-linear regressions were applied to evaluate the ecological aggregate associations of the exposures with incidences of EOCRC.
UNASSIGNED: The global age-standardized incidence of EOCRC increased from 3.05 (3.03, 3.07) to 3.85 (3.83, 3.86) per 100,000 during 1990 and 2019. The incidence was higher in countries with high socioeconomic levels, and increased drastically in countries in East Asia and Caribbean, particularly Jamaica, Saudi Arabia and Vietnam. The GDP per capita, SDI, and SEVs of iron deficiency, alcohol use, high body-mass index, and child growth failure in earlier years were more closely related with the incidences of EOCRC in 2019. Exposures at ages 0-4, 5-9, 10-14 and 15-19 years were also associated with the incidences, particularly for the exposures at ages 15-19 years.
UNASSIGNED: The global incidence of EOCRC increased during past three decades. The large variations at regional and national level may be related with the distribution of risk exposures in early life.
UNASSIGNED: Data on the incidence and attributable risk factors of EOCRC were obtained from the GBD 2019. Temporal trends of age-standardized incidence were evaluated by average annual percentage change (AAPC). Early-life exposures were indicated as summary exposure values (SEV) of selected factors, SDI and GDP per capita in previous decades and at ages 0-4, 5-9, 10-14 and 15-19 years. Weighted linear or non-linear regressions were applied to evaluate the ecological aggregate associations of the exposures with incidences of EOCRC.
UNASSIGNED: The global age-standardized incidence of EOCRC increased from 3.05 (3.03, 3.07) to 3.85 (3.83, 3.86) per 100,000 during 1990 and 2019. The incidence was higher in countries with high socioeconomic levels, and increased drastically in countries in East Asia and Caribbean, particularly Jamaica, Saudi Arabia and Vietnam. The GDP per capita, SDI, and SEVs of iron deficiency, alcohol use, high body-mass index, and child growth failure in earlier years were more closely related with the incidences of EOCRC in 2019. Exposures at ages 0-4, 5-9, 10-14 and 15-19 years were also associated with the incidences, particularly for the exposures at ages 15-19 years.
UNASSIGNED: The global incidence of EOCRC increased during past three decades. The large variations at regional and national level may be related with the distribution of risk exposures in early life.
摘要：
■早发性结直肠癌（EOCRC）的发病率正在全球增加。这项研究旨在描述发病率的时间趋势，并根据GBD2019在国家一级探索早期生命中的相关风险暴露。
■EOCRC的发生率和归因危险因素的数据来自GBD2019。通过年平均百分比变化（AAPC）评估年龄标准化发病率的时间趋势。早期暴露被表示为选定因素的汇总暴露值(SEV)，过去几十年以及0-4、5-9、10-14和15-19岁年龄段的SDI和人均GDP。应用加权线性或非线性回归来评估暴露与EOCRC发生率的生态总体关联。
■在1990年和2019年期间，EOCRC的全球年龄标准化发病率从3.05（3.03，3.07）增加到3.85（3.83，3.86）/100,000。在社会经济水平较高的国家发病率较高，在东亚和加勒比国家大幅增加，尤其是牙买加,沙特阿拉伯和越南。人均GDP,SDI,和缺铁的SEVs，酒精使用,身体质量指数高,早期儿童生长障碍与2019年EOCRC的发病率密切相关。0-4岁、5-9岁、10-14岁和15-19岁的接触也与发病率相关，特别是对于15-19岁的暴露。
■在过去的三十年中，EOCRC的全球发病率增加。区域和国家层面的巨大差异可能与生命早期风险暴露的分布有关。
■EOCRC的发生率和归因危险因素的数据来自GBD2019。通过年平均百分比变化（AAPC）评估年龄标准化发病率的时间趋势。早期暴露被表示为选定因素的汇总暴露值(SEV)，过去几十年以及0-4、5-9、10-14和15-19岁年龄段的SDI和人均GDP。应用加权线性或非线性回归来评估暴露与EOCRC发生率的生态总体关联。
■在1990年和2019年期间，EOCRC的全球年龄标准化发病率从3.05（3.03，3.07）增加到3.85（3.83，3.86）/100,000。在社会经济水平较高的国家发病率较高，在东亚和加勒比国家大幅增加，尤其是牙买加,沙特阿拉伯和越南。人均GDP,SDI,和缺铁的SEVs，酒精使用,身体质量指数高,早期儿童生长障碍与2019年EOCRC的发病率密切相关。0-4岁、5-9岁、10-14岁和15-19岁的接触也与发病率相关，特别是对于15-19岁的暴露。
■在过去的三十年中，EOCRC的全球发病率增加。区域和国家层面的巨大差异可能与生命早期风险暴露的分布有关。
