PDF(Pubmed)
Abstract：
BACKGROUND: Craniopharyngioma (CP) is a rare malformational tumor characterized by high rates of recurrence and morbid obesity. However, the role of inflammatory mediators in obesity and the prognosis of patients with CP remains unknown. Therefore, the present study aimed to analyze associations of inflammatory mediators with weight-related outcomes and the prognosis of patients with CP.
METHODS: A total of 130 consecutive patients with CP were included in this study. The expression levels of seven inflammatory mediators and the plasma leptin concentration were investigated. Clinical parameters, weight changes, new-onset obesity, and progression-free survival (PFS) were recorded. The relationships between inflammatory mediators, clinicopathologic parameters, weight-related outcomes, and PFS were explored.
RESULTS: Compared with those in normal pituitary tissue, the expressions of inflammatory mediators in tumor tissue were higher. Higher expression levels of CXCL1 and CXCL8 were identified as independent risk factors for significant weight gain, and CXCL1 and TNF were identified as independent risk factors for new-onset postoperative obesity. Poor PFS was associated with higher expression levels of CXCL1, CXCL8, IL1A, IL6, and TNF.
CONCLUSIONS: The present study revealed that inflammatory mediators are associated with morbid obesity in patients with CP. Inflammatory mediators may be the critical bridge between elevated leptin and weight-related outcomes. Additionally, PFS was associated with the expression of inflammatory mediators. Further research is needed to elucidate the underlying mechanisms of inflammatory mediators and their potential as targets for novel therapies for CP.
METHODS: A total of 130 consecutive patients with CP were included in this study. The expression levels of seven inflammatory mediators and the plasma leptin concentration were investigated. Clinical parameters, weight changes, new-onset obesity, and progression-free survival (PFS) were recorded. The relationships between inflammatory mediators, clinicopathologic parameters, weight-related outcomes, and PFS were explored.
RESULTS: Compared with those in normal pituitary tissue, the expressions of inflammatory mediators in tumor tissue were higher. Higher expression levels of CXCL1 and CXCL8 were identified as independent risk factors for significant weight gain, and CXCL1 and TNF were identified as independent risk factors for new-onset postoperative obesity. Poor PFS was associated with higher expression levels of CXCL1, CXCL8, IL1A, IL6, and TNF.
CONCLUSIONS: The present study revealed that inflammatory mediators are associated with morbid obesity in patients with CP. Inflammatory mediators may be the critical bridge between elevated leptin and weight-related outcomes. Additionally, PFS was associated with the expression of inflammatory mediators. Further research is needed to elucidate the underlying mechanisms of inflammatory mediators and their potential as targets for novel therapies for CP.
摘要：
背景：颅咽管瘤（CP）是一种罕见的畸形性肿瘤，其特征是高复发率和病态肥胖。然而,炎症介质在肥胖和CP患者预后中的作用尚不清楚.因此,本研究旨在分析炎症介质与CP患者体重相关结局和预后的关系.
方法：本研究共纳入130例CP患者。研究了7种炎症介质的表达水平和血浆瘦素浓度。临床参数,体重变化,新发肥胖，记录无进展生存期（PFS）。炎症介质之间的关系，临床病理参数，与体重相关的结果，和PFS进行了探索。
结果：与正常垂体组织相比，肿瘤组织中炎症介质的表达较高。CXCL1和CXCL8的较高表达水平被确定为显著体重增加的独立危险因素。CXCL1和TNF被确定为术后新发肥胖的独立危险因素。PFS差与CXCL1、CXCL8、IL1A、IL6和TNF。
结论：本研究显示，在CP患者中，炎症介质与病态肥胖有关。炎症介质可能是瘦素升高和体重相关结果之间的关键桥梁。此外,PFS与炎症介质的表达有关。需要进一步的研究来阐明炎症介质的潜在机制及其作为CP新疗法靶标的潜力。
方法：本研究共纳入130例CP患者。研究了7种炎症介质的表达水平和血浆瘦素浓度。临床参数,体重变化,新发肥胖，记录无进展生存期（PFS）。炎症介质之间的关系，临床病理参数，与体重相关的结果，和PFS进行了探索。
结果：与正常垂体组织相比，肿瘤组织中炎症介质的表达较高。CXCL1和CXCL8的较高表达水平被确定为显著体重增加的独立危险因素。CXCL1和TNF被确定为术后新发肥胖的独立危险因素。PFS差与CXCL1、CXCL8、IL1A、IL6和TNF。
结论：本研究显示，在CP患者中，炎症介质与病态肥胖有关。炎症介质可能是瘦素升高和体重相关结果之间的关键桥梁。此外,PFS与炎症介质的表达有关。需要进一步的研究来阐明炎症介质的潜在机制及其作为CP新疗法靶标的潜力。
