PDF(Pubmed)
Abstract：
Associations between migraine and retinal vascular occlusion have been reported, but there is no large-scale and comprehensive study. Therefore, we aimed to determine risks of retinal vascular occlusion in patients with migraine. Using the Taiwan National Health Insurance Research Database from 2009 to 2020, we enrolled 628,760 patients with migraine and 628,760 matched individuals without migraine. Study outcomes were diagnoses of retinal vascular occlusion, including retinal artery occlusion (RAO) and retinal vein occlusion (RVO). Adjusted hazard ratio (aHR) of retinal vascular occlusion related to migraine was estimated. The cumulative incidences of subsequent retinal vascular occlusion, RAO, and RVO were significantly higher in migraine patients compared with controls (0.31% vs. 0.21%; 0.09% vs. 0.05%; 0.22% vs. 0.17%; all p < 0.001). The hazards of retinal vascular occlusion, RAO, and RVO were significantly greater in the migraine group (aHR, 1.69 [95% CI, 1.57, 1.83], 2.13 [95% CI, 1.84, 2.48] and 1.53 [95% CI, 1.40, 1.68], respectively). Risks of retinal vascular occlusion were significantly higher in migraine both with aura (MA) and without aura (MO) (aHR, 1.77 [95% CI, 1.58, 1.98], and 1.92 [95% CI, 1.64, 2.25]). Among patients with migraine, nonsteroidal anti-inflammatory drugs, propranolol, and flunarizine significantly reduce their risks of retinal vascular occlusion (aHR, 0.19 [95% CI, 0.16, 0.22], 0.73 [95% CI, 0.62, 0.86], 0.84 [95% CI, 0.76, 0.93]). Migraine, MA and MO are independently associated with higher risks of retinal vascular occlusion, RAO, and RVO.
摘要：
偏头痛和视网膜血管阻塞之间的关联已被报道，但是没有大规模和全面的研究。因此,我们旨在确定偏头痛患者视网膜血管阻塞的风险.使用2009年至2020年的台湾国民健康保险研究数据库，我们招募了628,760名偏头痛患者和628,760名没有偏头痛的匹配个体。研究结果是诊断为视网膜血管阻塞，包括视网膜动脉阻塞(RAO)和视网膜静脉阻塞(RVO)。估计与偏头痛相关的视网膜血管阻塞的调整风险比（aHR）。随后视网膜血管阻塞的累积发生率，RAO,与对照组相比，偏头痛患者的RVO明显更高(0.31%vs.0.21%；0.09%与0.05%；0.22%vs.0.17%；所有p<0.001)。视网膜血管阻塞的危害,RAO,和RVO在偏头痛组中显著更大(aHR，1.69[95%CI，1.57，1.83]，2.13[95%CI，1.84，2.48]和1.53[95%CI，1.40，1.68]，分别)。在有先兆（MA）和无先兆（MO）的偏头痛中，视网膜血管阻塞的风险显着升高（aHR，1.77[95%CI，1.58，1.98]，和1.92[95%CI，1.64，2.25]）。在偏头痛患者中，非甾体抗炎药，普萘洛尔,和氟桂利嗪显著降低视网膜血管阻塞的风险(aHR，0.19[95%CI，0.16，0.22]，0.73[95%CI，0.62，0.86]，0.84[95%CI，0.76，0.93]）。偏头痛,MA和MO与视网膜血管阻塞的高风险独立相关，RAO,和RVO。
