关键词: Maternal medicine PREVENTIVE MEDICINE Primary Prevention Reproductive medicine

Mesh : Humans Aspirin / administration & dosage Female Pregnancy Fertilization in Vitro Hypertension, Pregnancy-Induced / prevention & control Pre-Eclampsia / prevention & control Platelet Aggregation Inhibitors / administration & dosage Review Literature as Topic

来  源:   DOI:10.1136/bmjopen-2023-080353   PDF(Pubmed)

Abstract:
BACKGROUND: Pregnancies resulting from in vitro fertilisation are associated with an increased risk of developing hypertensive disorders of pregnancy, such as preeclampsia, when compared with naturally conceived pregnancies.
OBJECTIVE: The efficacy of aspirin prophylaxis to reduce the incidence of preeclampsia is well established in naturally conceived pregnancies identified as high risk for developing preeclampsia. However, the efficacy of aspirin to reduce the rate of preeclampsia for all pregnancies resulting from in vitro fertilisation remains uncertain, although in vitro fertilisation conception is a well-known risk factor for preeclampsia. Therefore, the purpose of this scoping review is to provide a comprehensive overview of the current literature regarding the use of low-dose aspirin to prevent hypertensive disorders of pregnancy after in vitro fertilisation.
METHODS: This review will identify all peer-reviewed published articles including pregnant women who underwent embryo transfer after in vitro fertilisation and were prescribed low-dose aspirin to reduce the risk of hypertensive disorders of pregnancy.
METHODS: We have devised a comprehensive search strategy to systematically identify pertinent studies published from January 2000 until May 2024, within the Medline (PubMed interface), Embase and Scopus databases. The search strategy is based on the keywords \'aspirin,\' \'pregnancy-induced hypertension,\' and (\'in vitro fertilization\' OR \'oocyte donation\' OR \'embryo transfer\' OR \'donor conception\'). Two reviewers will independently screen the titles, abstracts and full-text articles to select the relevant articles, using the Covidence software.
BACKGROUND: No patients are involved in this study. This study aims to be published in a peer-reviewed journal and could be presented at a conference.
摘要:
背景:体外受精导致的妊娠与发生妊娠期高血压疾病的风险增加有关,如先兆子痫,与自然怀孕相比。
目的:在被确定为先兆子痫高风险的自然妊娠中,阿司匹林预防降低先兆子痫发生率的功效已得到证实。然而,阿司匹林对所有体外受精妊娠的先兆子痫发生率的降低效果仍不确定,尽管体外受精是子痫前期的一个众所周知的危险因素。因此,本研究的目的是全面概述目前有关使用小剂量阿司匹林预防体外受精后妊娠高血压疾病的文献.
方法:本综述将确定所有同行评审发表的文章,包括在体外受精后接受胚胎移植的孕妇,并服用低剂量阿司匹林以降低妊娠期高血压疾病的风险。
方法:我们设计了一种全面的搜索策略,以系统地识别2000年1月至2024年5月在Medline(PubMed界面)内发表的相关研究,Embase和Scopus数据库。搜索策略是基于关键词\'阿司匹林,\'\'妊娠高血压,\'和(\'体外受精\'或\'卵母细胞捐赠\'或\'胚胎移植\'或\'供体受孕\')。两名审阅者将独立筛选标题,摘要和全文文章选择相关文章,使用Covidence软件。
背景:本研究没有患者参与。这项研究旨在发表在同行评审的期刊上,并可以在会议上发表。
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