PDF(Pubmed)
Abstract：
Stressors can initiate a cascade of central and peripheral changes that modulate mesocorticolimbic dopaminergic circuits and, ultimately, behavioral response to rewards. Driven by the absence of conclusive evidence on this topic and the Research Domain Criteria framework, random-effects meta-analyses were adopted to quantify the effects of acute stressors on reward responsiveness, valuation, and learning in rodent and human subjects. In rodents, acute stress reduced reward responsiveness (g = -1.43) and valuation (g = -0.32), while amplifying reward learning (g = 1.17). In humans, acute stress had marginal effects on valuation (g = 0.25), without affecting responsiveness and learning. Moderation analyses suggest that acute stress neither has unitary effects on reward processing in rodents nor in humans and that the duration of the stressor and specificity of reward experience (i.e., food vs drugs) may produce qualitatively and quantitatively different behavioral endpoints. Subgroup analyses failed to reduce heterogeneity, which, together with the presence of publication bias, pose caution on the conclusions that can be drawn and point to the need of guidelines for the conduction of future studies in the field.
摘要：
压力源可以引发中枢和外周变化的级联反应，调节中皮质边缘多巴胺能回路，最终,对奖励的行为反应。由于缺乏关于这一主题的确凿证据和研究领域标准框架，采用随机效应荟萃分析来量化急性应激源对奖励反应的影响，估价，在啮齿动物和人类科目中学习。在啮齿动物中，急性压力降低了奖励反应性(g=-1.43)和估值(g=-0.32)，同时放大奖励学习(g=1.17)。在人类中,急性应激对估值有边际效应(g=0.25)，而不影响反应能力和学习。适度分析表明，急性压力对啮齿动物和人类的奖励处理都没有统一影响，并且压力源的持续时间和奖励体验的特异性（即，食物与药物)可能在质量和数量上产生不同的行为终点。亚组分析未能减少异质性，which,加上出版偏见的存在，对可以得出的结论持谨慎态度，并指出需要指导该领域未来研究的开展。
