PDF(Pubmed)
Abstract：
UNASSIGNED: The Geriatric Nutritional Risk Index (GNRI) indicates nutritional status based on serum albumin concentration and ideal body weight. Pretreatment GNRI has been suggested as a prognostic factor for various malignancies. However, little is known about the clinical value of GNRI for small-cell lung cancer (SCLC), especially in elderly patients.
UNASSIGNED: We retrospectively analyzed 53 elderly (≥71) patients with extensive-disease (ED) SCLC treated with first-line platinum-doublet chemotherapy in relation to the pretreatment GNRI level in a real-world setting.
UNASSIGNED: Thirty-six patients with a low GNRI (<92) had statistically poorer progression-free survival (PFS) and overall survival (OS) than 17 patients with a high GNRI (≥92) (median PFS=80 days vs. 133 days, respectively; p=0.002; median OS=123 days vs. 274 days, respectively; p=0.004). In a multivariate analysis, a low GNRI was also an independent poor prognostic factor for PFS [hazard ratio (HR)=0.396; 95% confidence interval (CI)=0.199-0.789; p=0.008] and OS (HR=0.295; 95%CI=0.143-0.608; p<0.001).
UNASSIGNED: The GNRI might be a predictive and prognostic marker in elderly patients with ED-SCLC treated with platinum-doublet chemotherapy.
UNASSIGNED: We retrospectively analyzed 53 elderly (≥71) patients with extensive-disease (ED) SCLC treated with first-line platinum-doublet chemotherapy in relation to the pretreatment GNRI level in a real-world setting.
UNASSIGNED: Thirty-six patients with a low GNRI (<92) had statistically poorer progression-free survival (PFS) and overall survival (OS) than 17 patients with a high GNRI (≥92) (median PFS=80 days vs. 133 days, respectively; p=0.002; median OS=123 days vs. 274 days, respectively; p=0.004). In a multivariate analysis, a low GNRI was also an independent poor prognostic factor for PFS [hazard ratio (HR)=0.396; 95% confidence interval (CI)=0.199-0.789; p=0.008] and OS (HR=0.295; 95%CI=0.143-0.608; p<0.001).
UNASSIGNED: The GNRI might be a predictive and prognostic marker in elderly patients with ED-SCLC treated with platinum-doublet chemotherapy.
摘要：
■老年营养风险指数（GNRI）根据血清白蛋白浓度和理想体重指示营养状况。预处理GNRI已被认为是各种恶性肿瘤的预后因素。然而,关于GNRI对小细胞肺癌（SCLC）的临床价值知之甚少，尤其是老年患者。
■我们回顾性分析了53例老年(≥71例)广泛性疾病(ED)SCLC患者接受一线铂双联化疗与治疗前GNRI水平的关系。
■36例GNRI低（<92）患者的无进展生存期（PFS）和总生存期（OS）在统计学上比17例GNRI高（≥92）患者差（中位PFS=80天vs.133天,分别为；p=0.002；中位OS=123天与274天,分别为；p=0.004)。在多变量分析中，低GNRI也是PFS的独立不良预后因素[风险比(HR)=0.396;95%置信区间(CI)=0.199-0.789;p=0.008]和OS(HR=0.295;95CI=0.143-0.608;p<0.001).
■GNRI可能是接受铂类双联化疗的老年ED-SCLC患者的预测和预后标志物。
■我们回顾性分析了53例老年(≥71例)广泛性疾病(ED)SCLC患者接受一线铂双联化疗与治疗前GNRI水平的关系。
■36例GNRI低（<92）患者的无进展生存期（PFS）和总生存期（OS）在统计学上比17例GNRI高（≥92）患者差（中位PFS=80天vs.133天,分别为；p=0.002；中位OS=123天与274天,分别为；p=0.004)。在多变量分析中，低GNRI也是PFS的独立不良预后因素[风险比(HR)=0.396;95%置信区间(CI)=0.199-0.789;p=0.008]和OS(HR=0.295;95CI=0.143-0.608;p<0.001).
■GNRI可能是接受铂类双联化疗的老年ED-SCLC患者的预测和预后标志物。
