PDF(Pubmed)
Abstract：
UNASSIGNED: Haematological abnormalities are common among tuberculosis patients but there is dearth of information on their value as prognostic markers in Multidrug resistant tuberculosis patients. This study examined the association between complete blood count variables and drug resistant tuberculosis.
UNASSIGNED: Nighty (90) consenting adults comprising 30 Drug Resistant Tuberculosis patients (DR-TB), 30 Drug susceptible tuberculosis patients (DS-TB) and 30 healthy participants were recruited in this study. Ethical approval was obtained from Oyo State Ministry of Health Institutional Review Board while patients\' demographic data were collected using structured questionnaire. Five milliliters (5mL) of blood samples were collected in EDTA bottle. Haematological parameters were analysed using impedance technique and Mindary-BG5380 5-part automated system.
UNASSIGNED: The mean hemoglobin levels were significantly lower in DR-TB patients (11.70 ± 2.73 g/dL) than in DS-TB patients (8.33 ± 9.56 fL), with a mean difference of -3.37 ± 12.29 g/dL. The mean MCH and MCHC levels were also slightly lower in DR-TB patients (26.17 ± 3.44 pg and 30.41 ± 1.92 g/dL, respectively), but the differences were not statistically significant. The WBC count was similar in both groups (8.20 ± 3.80 × 10^9 /L and 8.45 ± 3.63 × 10^9 /L, respectively).
UNASSIGNED: The mean hemoglobin levels were significantly lower in DR-TB patients than in DS-TB patients which may be due to the increased inflammation associated with DR-TB. The WBC count was similar in both groups, suggesting that the immune system is responding similarly to the infection in both DR-TB and DS-TB patients.
UNASSIGNED: In the meantime, healthcare providers should be aware of these potential differences and use them to inform their diagnosis and treatment of patients with tuberculosis.
UNASSIGNED: Nighty (90) consenting adults comprising 30 Drug Resistant Tuberculosis patients (DR-TB), 30 Drug susceptible tuberculosis patients (DS-TB) and 30 healthy participants were recruited in this study. Ethical approval was obtained from Oyo State Ministry of Health Institutional Review Board while patients\' demographic data were collected using structured questionnaire. Five milliliters (5mL) of blood samples were collected in EDTA bottle. Haematological parameters were analysed using impedance technique and Mindary-BG5380 5-part automated system.
UNASSIGNED: The mean hemoglobin levels were significantly lower in DR-TB patients (11.70 ± 2.73 g/dL) than in DS-TB patients (8.33 ± 9.56 fL), with a mean difference of -3.37 ± 12.29 g/dL. The mean MCH and MCHC levels were also slightly lower in DR-TB patients (26.17 ± 3.44 pg and 30.41 ± 1.92 g/dL, respectively), but the differences were not statistically significant. The WBC count was similar in both groups (8.20 ± 3.80 × 10^9 /L and 8.45 ± 3.63 × 10^9 /L, respectively).
UNASSIGNED: The mean hemoglobin levels were significantly lower in DR-TB patients than in DS-TB patients which may be due to the increased inflammation associated with DR-TB. The WBC count was similar in both groups, suggesting that the immune system is responding similarly to the infection in both DR-TB and DS-TB patients.
UNASSIGNED: In the meantime, healthcare providers should be aware of these potential differences and use them to inform their diagnosis and treatment of patients with tuberculosis.
摘要：
■血液异常在结核病患者中很常见，但缺乏有关其在耐多药结核病患者中作为预后标志物的价值的信息。这项研究检查了全血细胞计数变量与耐药结核病之间的关系。
■由30名耐药结核病患者（DR-TB）组成的成年人（90）同意，本研究招募了30名药物易感结核病患者（DS-TB）和30名健康参与者。从奥约州卫生部机构审查委员会获得伦理批准，同时使用结构化问卷收集患者的人口统计数据。在EDTA瓶中收集5毫升(5mL)血液样品。使用阻抗技术和Mindary-BG53805部分自动系统分析了血液学参数。
■DR-TB患者的平均血红蛋白水平（11.70±2.73g/dL）明显低于DS-TB患者（8.33±9.56fL），平均差为-3.37±12.29g/dL。DR-TB患者的平均MCH和MCHC水平也略低（26.17±3.44pg和30.41±1.92g/dL，分别)，但差异无统计学意义。两组白细胞计数相似（8.20±3.80×10^9/L和8.45±3.63×10^9/L，分别)。
DR-TB患者的平均血红蛋白水平明显低于DS-TB患者，这可能是由于与DR-TB相关的炎症增加。两组的白细胞计数相似，这表明免疫系统对DR-TB和DS-TB患者的感染反应相似。
■同时,医疗保健提供者应该意识到这些潜在的差异，并利用它们来告知他们对结核病患者的诊断和治疗。
■由30名耐药结核病患者（DR-TB）组成的成年人（90）同意，本研究招募了30名药物易感结核病患者（DS-TB）和30名健康参与者。从奥约州卫生部机构审查委员会获得伦理批准，同时使用结构化问卷收集患者的人口统计数据。在EDTA瓶中收集5毫升(5mL)血液样品。使用阻抗技术和Mindary-BG53805部分自动系统分析了血液学参数。
■DR-TB患者的平均血红蛋白水平（11.70±2.73g/dL）明显低于DS-TB患者（8.33±9.56fL），平均差为-3.37±12.29g/dL。DR-TB患者的平均MCH和MCHC水平也略低（26.17±3.44pg和30.41±1.92g/dL，分别)，但差异无统计学意义。两组白细胞计数相似（8.20±3.80×10^9/L和8.45±3.63×10^9/L，分别)。
DR-TB患者的平均血红蛋白水平明显低于DS-TB患者，这可能是由于与DR-TB相关的炎症增加。两组的白细胞计数相似，这表明免疫系统对DR-TB和DS-TB患者的感染反应相似。
■同时,医疗保健提供者应该意识到这些潜在的差异，并利用它们来告知他们对结核病患者的诊断和治疗。
