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Abstract：
The execution of goal-oriented behaviours requires a spatially coherent alignment between sensory and motor maps. The current model for sensorimotor transformation in the superior colliculus relies on the topographic mapping of static spatial receptive fields onto movement endpoints1-6. Here, to experimentally assess the validity of this canonical static model of alignment, we dissected the visuo-motor network in the superior colliculus and performed in vivo intracellular and extracellular recordings across layers, in restrained and unrestrained conditions, to assess both the motor and the visual tuning of individual motor and premotor neurons. We found that collicular motor units have poorly defined visual static spatial receptive fields and respond instead to kinetic visual features, revealing the existence of a direct alignment in vectorial space between sensory and movement vectors, rather than between spatial receptive fields and movement endpoints as canonically hypothesized. We show that a neural network built according to these kinetic alignment principles is ideally placed to sustain ethological behaviours such as the rapid interception of moving and static targets. These findings reveal a novel dimension of the sensorimotor alignment process. By extending the alignment from the static to the kinetic domain this work provides a novel conceptual framework for understanding the nature of sensorimotor convergence and its relevance in guiding goal-directed behaviours.
摘要：
以目标为导向的行为的执行需要感觉图和运动图之间的空间一致性。当前上丘感觉运动转换的模型依赖于静态空间感受野在运动终点1-6上的地形图。这里,为了通过实验评估这种标准静态对齐模型的有效性，我们解剖了上丘的视觉运动网络，并在体内进行了跨层的细胞内和细胞外记录，在约束和不约束的条件下，评估单个运动和前运动神经元的运动和视觉调谐。我们发现，丘运动单位的视觉静态空间感受野定义不清，而是对动力学视觉特征的响应。揭示了感觉矢量和运动矢量之间矢量空间中直接对齐的存在，而不是像经典假设的那样在空间感受野和运动端点之间。我们表明，根据这些动力学对准原理构建的神经网络非常适合维持行为学行为，例如快速拦截移动和静态目标。这些发现揭示了感觉运动对准过程的新维度。通过将对齐从静态域扩展到动力学域，这项工作提供了一个新颖的概念框架，用于理解感觉运动收敛的性质及其在指导目标导向行为中的相关性。
