PDF(Pubmed)
Abstract：
The present study is focused on evaluating acaricidal activity and chemical compositions of Erigeron acer root, which was identified as a promising candidate among fifteen Mongolian plant extracts tested for acaricidal activity. The acaricidal effect was evaluated against Haemaphysalis longicornis, assessed for toxicity to normal human skin fibroblast, and analyzed for its chemical constituents. The acetone extract of E. acer root showed significant activity against H. longicornis, with a lethal concentration (LC50) of 5.31 mg/mL and low toxicity, evidenced by a cytotoxic concentration (CC50) of 267.00 µg/mL. Using liquid chromatography-tandem mass spectrometry and molecular networking, thirteen natural compounds were identified, including pyrrolidines, alkaloids, fatty acids, and flavonoids, highlighting the efficacy of E. acer root extract as an effective acaricide against H. longicornis and offering insights for developing new tick control solutions.
摘要：
本研究的重点是评估Erigeronacer根的杀螨活性和化学成分，在15种测试杀螨活性的蒙古植物提取物中，它被确定为有希望的候选物。对长尾骨干的杀螨作用进行了评估，评估对正常人皮肤成纤维细胞的毒性，并对其化学成分进行了分析。紫菜根的丙酮提取物对长尾H.longicornis具有明显的活性，具有5.31mg/mL的致死浓度（LC50）和低毒性，由267.00µg/mL的细胞毒性浓度（CC50）证明。使用液相色谱-串联质谱和分子网络，鉴定了13种天然化合物，包括吡咯烷,生物碱，脂肪酸，和类黄酮，强调了E.acer根提取物作为一种有效的杀螨剂对H.longicornis的功效，并为开发新的蜱控制解决方案提供了见解。
