Abstract：
The dimeric kinesin-8 motors have the biological function of depolymerizing microtubules (MTs) from the plus end. However, the molecular mechanism of the depolymerization promoted by the kinesin-8 motors is still undetermined. Here, a model is proposed for the MT depolymerization by the kinesin-8 motors. Based on the model, the dynamics of depolymerization in the presence of the single motor at the MT plus end under no load and under load on the motor is studied theoretically. The dynamics of depolymerization in the presence of multiple motors at the MT plus end is also analyzed. The theoretical results explain well the available experimental data. The studies can also be applicable to other families of kinesin motors such as kinesin-13 mitotic centromere-associated kinesin motors that have the ability to depolymerize MTs.
摘要：
二聚体驱动蛋白-8马达具有从正端解聚微管（MT）的生物学功能。然而,kinesin-8电机促进解聚的分子机制仍不确定。这里,提出了用kinesin-8电机进行MT解聚的模型。基于模型,从理论上研究了在空载和电动机负载下，在MT加端存在单个电动机的情况下的解聚动力学。还分析了在MT加端存在多个电机的情况下的解聚动力学。理论结果很好地解释了可用的实验数据。这些研究也可以适用于其他家族的驱动蛋白马达，例如驱动蛋白-13有丝分裂着丝粒相关的驱动蛋白马达，它们具有解聚MT的能力。
