Abstract：
Metalloproteins represents more than one third of human proteome, with huge variation in physiological functions and pathological implications, depending on the metal/metals involved and tissue context. Their functions range from catalysis, bioenergetics, redox, to DNA repair, cell proliferation, signaling, transport of vital elements, and immunity. The human metalloproteomic studies revealed that many families of metalloproteins along with individual metalloproteins are dysregulated under several clinical conditions. Also, several sorts of interaction between redox- active or redox- inert metalloproteins are observed in health and disease. Metalloproteins profiling shows distinct alterations in neurodegenerative diseases, cancer, inflammation, infection, diabetes mellitus, among other diseases. This makes metalloproteins -either individually or as families- a promising target for several therapeutic approaches. Inhibitors and activators of metalloenzymes, metal chelators, along with artificial metalloproteins could be versatile in diagnosis and treatment of several diseases, in addition to other biomedical and industrial applications.
摘要：
金属蛋白占人类蛋白质组的三分之一以上，生理功能和病理意义的巨大差异，取决于所涉及的金属/金属和组织环境。它们的功能范围从催化，生物能学，氧化还原,DNA修复，细胞增殖，信令,重要元素的运输，和豁免权。人类金属蛋白质组学研究表明，在几种临床条件下，许多金属蛋白家族以及单个金属蛋白均失调。此外，在健康和疾病中观察到氧化还原活性或氧化还原惰性金属蛋白之间的几种相互作用。金属蛋白谱分析显示神经退行性疾病的明显改变，癌症,炎症,感染,糖尿病,在其他疾病中。这使得金属蛋白-无论是单独还是作为家族-成为几种治疗方法的有希望的靶标。金属酶的抑制剂和活化剂，金属螯合剂，与人工金属蛋白一起可以在多种疾病的诊断和治疗中用途广泛，除了其他生物医学和工业应用。
