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Abstract：
To retrospectively investigate the impact of pre-treatment Extracellular Volume Fraction (ECV) measured by Computed Tomography (CT) on the response of primary lesions to preoperative chemotherapy in abdominal neuroblastoma.
A total of seventy-five patients with abdominal neuroblastoma were retrospectively included in the study. The regions of interest for the primary lesion and aorta were determined on unenhanced and equilibrium phase CT images before treatment, and their average CT values were measured. Based on patient hematocrit and average CT values, the ECV was calculated. The correlation between ECV and the reduction in primary lesion volume was examined. A receiver operating characteristic curve was generated to assess the predictive performance of ECV for a very good partial response of the primary lesion.
There was a negative correlation between primary lesion volume reduction and ECV (r = -0.351, p = 0.002), and primary lesions with very good partial response had lower ECV (p < 0.001). The area under the curve for ECV in predicting the very good partial response of primary lesion was 0.742 (p < 0.001), with a 95 % Confidence Interval of 0.628 to 0.836. The optimal cut-off value was 0.28, and the sensitivity and specificity were 62.07 % and 84.78 %, respectively.
The measurement of pre-treatment ECV on CT images demonstrates a significant correlation with the response of the primary lesion to preoperative chemotherapy in abdominal neuroblastoma.
A total of seventy-five patients with abdominal neuroblastoma were retrospectively included in the study. The regions of interest for the primary lesion and aorta were determined on unenhanced and equilibrium phase CT images before treatment, and their average CT values were measured. Based on patient hematocrit and average CT values, the ECV was calculated. The correlation between ECV and the reduction in primary lesion volume was examined. A receiver operating characteristic curve was generated to assess the predictive performance of ECV for a very good partial response of the primary lesion.
There was a negative correlation between primary lesion volume reduction and ECV (r = -0.351, p = 0.002), and primary lesions with very good partial response had lower ECV (p < 0.001). The area under the curve for ECV in predicting the very good partial response of primary lesion was 0.742 (p < 0.001), with a 95 % Confidence Interval of 0.628 to 0.836. The optimal cut-off value was 0.28, and the sensitivity and specificity were 62.07 % and 84.78 %, respectively.
The measurement of pre-treatment ECV on CT images demonstrates a significant correlation with the response of the primary lesion to preoperative chemotherapy in abdominal neuroblastoma.
摘要：
目的：回顾性研究腹部神经母细胞瘤治疗前计算机断层扫描（CT）测量细胞外体积分数（ECV）对原发灶对术前化疗反应的影响。
方法：回顾性研究共75例腹部神经母细胞瘤患者。治疗前在未增强和平衡相CT图像上确定原发性病变和主动脉的感兴趣区域，并测量其平均CT值。根据患者血细胞比容和平均CT值,计算ECV。检查了ECV与原发性病变体积减少之间的相关性。生成受试者工作特征曲线以评估ECV对于原发性病变的非常好的部分响应的预测性能。
结果：原发病灶体积减少与ECV呈负相关（r=-0.351，p=0.002），部分反应良好的原发病灶的ECV较低(p<0.001).ECV预测原发病变部分反应的曲线下面积为0.742(p<0.001),95%的置信区间为0.628至0.836。最佳截断值为0.28,灵敏度和特异度分别为62.07%和84.78%,分别。
结论：在CT图像上测量治疗前ECV与腹部神经母细胞瘤的原发病灶对术前化疗的反应显著相关。
方法：回顾性研究共75例腹部神经母细胞瘤患者。治疗前在未增强和平衡相CT图像上确定原发性病变和主动脉的感兴趣区域，并测量其平均CT值。根据患者血细胞比容和平均CT值,计算ECV。检查了ECV与原发性病变体积减少之间的相关性。生成受试者工作特征曲线以评估ECV对于原发性病变的非常好的部分响应的预测性能。
结果：原发病灶体积减少与ECV呈负相关（r=-0.351，p=0.002），部分反应良好的原发病灶的ECV较低(p<0.001).ECV预测原发病变部分反应的曲线下面积为0.742(p<0.001),95%的置信区间为0.628至0.836。最佳截断值为0.28,灵敏度和特异度分别为62.07%和84.78%,分别。
结论：在CT图像上测量治疗前ECV与腹部神经母细胞瘤的原发病灶对术前化疗的反应显著相关。
