Abstract：
OBJECTIVE: This study aimed to investigate the demographics, clinical characteristics, and management outcomes of patients with acute infectious endophthalmitis (AIE).
METHODS: This retrospective chart review was conducted on all patients admitted with the clinical diagnosis of infectious endophthalmitis from 2017 to 2022. Demographic data, patients\' clinical characteristics, the type of acute infectious endophthalmitis (post-operative, post-traumatic, bleb-associated, and endogenous endophthalmitis), the type of surgical procedure in the post-operative cases, the microbiologic analysis results of vitreous samples, therapeutic measures, and visual outcomes of patients were recorded.
RESULTS: In this study, 182 participants, including 122 male (67%) and 60 (33%) female, were involved. The mean age of patients was 54.56 ± 21 years, with a range of 1-88 years old. The most prevalent type of AIE was post-operative (59.9%), followed by endogenous (19.2%), post-traumatic (17%), and bleb-associated (3.8%). The most common type of intraocular surgery in the post-operative subgroups of AIE patients was phacoemulsification (57.8%). The median (interquartile range) of the primary and final BCVA of patients was 1.5 (1.35, 1.85) and 0.65 (0.35, 1.35), respectively. Vitreous haziness grade (OR, 2.89; 95% CI, 1.11-5.74; p = 0.009) and the primary VA (OR, 60.34; 95% CI, 2.87-126.8; p = 0.008) revealed statistical significance for final vision loss.
CONCLUSIONS: AIE is a devastating condition with poor visual outcomes, which presents with acute inflammatory signs and symptoms regardless of its type. However, prompt and appropriate treatment leads to visual recovery to a functional level in many patients.
METHODS: This retrospective chart review was conducted on all patients admitted with the clinical diagnosis of infectious endophthalmitis from 2017 to 2022. Demographic data, patients\' clinical characteristics, the type of acute infectious endophthalmitis (post-operative, post-traumatic, bleb-associated, and endogenous endophthalmitis), the type of surgical procedure in the post-operative cases, the microbiologic analysis results of vitreous samples, therapeutic measures, and visual outcomes of patients were recorded.
RESULTS: In this study, 182 participants, including 122 male (67%) and 60 (33%) female, were involved. The mean age of patients was 54.56 ± 21 years, with a range of 1-88 years old. The most prevalent type of AIE was post-operative (59.9%), followed by endogenous (19.2%), post-traumatic (17%), and bleb-associated (3.8%). The most common type of intraocular surgery in the post-operative subgroups of AIE patients was phacoemulsification (57.8%). The median (interquartile range) of the primary and final BCVA of patients was 1.5 (1.35, 1.85) and 0.65 (0.35, 1.35), respectively. Vitreous haziness grade (OR, 2.89; 95% CI, 1.11-5.74; p = 0.009) and the primary VA (OR, 60.34; 95% CI, 2.87-126.8; p = 0.008) revealed statistical significance for final vision loss.
CONCLUSIONS: AIE is a devastating condition with poor visual outcomes, which presents with acute inflammatory signs and symptoms regardless of its type. However, prompt and appropriate treatment leads to visual recovery to a functional level in many patients.
摘要：
目的：本研究旨在调查人口统计学，临床特征,急性感染性眼内炎（AIE）患者的治疗结果。
方法：对2017年至2022年临床诊断为感染性眼内炎的所有患者进行回顾性分析。人口统计数据,患者的临床特征，急性感染性眼内炎的类型（术后，创伤后,气泡相关，和内源性眼内炎)，手术后病例的外科手术类型，玻璃体样品的微生物分析结果，治疗措施,并记录患者的视觉结果。
结果：在这项研究中，182名与会者包括122名男性(67%)和60名女性(33%)，参与其中。患者平均年龄为54.56±21岁,年龄在1-88岁之间。最常见的AIE类型是术后（59.9％），其次是内源性（19.2%），创伤后（17%），和泡相关(3.8%)。AIE患者术后亚组中最常见的眼内手术类型是超声乳化术（57.8％）。患者的主要和最终BCVA的中位数（四分位距）为1.5（1.35，1.85）和0.65（0.35，1.35），分别。玻璃体混浊等级(OR,2.89；95%CI，1.11-5.74；p=0.009）和主要VA（OR，60.34；95%CI，2.87-126.8；p=0.008）显示最终视力丧失的统计学意义。
结论：AIE是一种破坏性疾病，视力不良，无论其类型如何，都具有急性炎症体征和症状。然而,及时和适当的治疗导致许多患者的视力恢复到功能水平。
方法：对2017年至2022年临床诊断为感染性眼内炎的所有患者进行回顾性分析。人口统计数据,患者的临床特征，急性感染性眼内炎的类型（术后，创伤后,气泡相关，和内源性眼内炎)，手术后病例的外科手术类型，玻璃体样品的微生物分析结果，治疗措施,并记录患者的视觉结果。
结果：在这项研究中，182名与会者包括122名男性(67%)和60名女性(33%)，参与其中。患者平均年龄为54.56±21岁,年龄在1-88岁之间。最常见的AIE类型是术后（59.9％），其次是内源性（19.2%），创伤后（17%），和泡相关(3.8%)。AIE患者术后亚组中最常见的眼内手术类型是超声乳化术（57.8％）。患者的主要和最终BCVA的中位数（四分位距）为1.5（1.35，1.85）和0.65（0.35，1.35），分别。玻璃体混浊等级(OR,2.89；95%CI，1.11-5.74；p=0.009）和主要VA（OR，60.34；95%CI，2.87-126.8；p=0.008）显示最终视力丧失的统计学意义。
结论：AIE是一种破坏性疾病，视力不良，无论其类型如何，都具有急性炎症体征和症状。然而,及时和适当的治疗导致许多患者的视力恢复到功能水平。
