PDF(Pubmed)
Abstract：
Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts.
摘要：
在圣卡塔琳娜发现死亡的南美海狮中检测到了进化枝2.3.4.4b高致病性禽流感（HPAI）H5N1病毒，巴西,2023年10月。进行了全基因组测序和比较系统发育分析，以调查起源，遗传多样性,和H5N1病毒的人畜共患潜力。H5N1病毒属于进化枝2.3.4.4bH5N1病毒的B3.2基因型，在北美发现并传播到南美。它们获得了与哺乳动物宿主亲和力相关的新氨基酸取代。我们的研究提供了对巴西H5N1病毒的遗传景观的见解，强调了有助于它们可能适应哺乳动物宿主的连续进化过程。
