Abstract：
OBJECTIVE: Approximately 20-30 % of epilepsy patients exhibit negative findings on routine magnetic resonance imaging, and this condition is known as nonlesional epilepsy. Absence epilepsy (AE) is a prevalent form of nonlesional epilepsy. This study aimed to investigate the clinical diagnostic utility of regional homogeneity (ReHo) assessed through the support vector machine (SVM) approach for identifying AE.
METHODS: This research involved 102 healthy individuals and 93 AE patients. Resting-state functional magnetic resonance imaging was employed for data acquisition in all participants. ReHo analysis, coupled with SVM methodology, was utilized for data processing.
RESULTS: Compared to healthy control individuals, AE patients demonstrated significantly elevated ReHo values in the bilateral putamen, accompanied by decreased ReHo in the bilateral thalamus. SVM was used to differentiate patients with AE from healthy control individuals based on rs-fMRI data. A composite assessment of altered ReHo in the left putamen and left thalamus yielded the highest accuracy at 81.64 %, with a sensitivity of 95.41 % and a specificity of 69.23 %.
CONCLUSIONS: According to the results, altered ReHo values in the bilateral putamen and thalamus could serve as neuroimaging markers for AE, offering objective guidance for its diagnosis.
METHODS: This research involved 102 healthy individuals and 93 AE patients. Resting-state functional magnetic resonance imaging was employed for data acquisition in all participants. ReHo analysis, coupled with SVM methodology, was utilized for data processing.
RESULTS: Compared to healthy control individuals, AE patients demonstrated significantly elevated ReHo values in the bilateral putamen, accompanied by decreased ReHo in the bilateral thalamus. SVM was used to differentiate patients with AE from healthy control individuals based on rs-fMRI data. A composite assessment of altered ReHo in the left putamen and left thalamus yielded the highest accuracy at 81.64 %, with a sensitivity of 95.41 % and a specificity of 69.23 %.
CONCLUSIONS: According to the results, altered ReHo values in the bilateral putamen and thalamus could serve as neuroimaging markers for AE, offering objective guidance for its diagnosis.
摘要：
目的：大约20-30%的癫痫患者在常规磁共振成像中表现为阴性，这种情况被称为非病灶性癫痫。失神癫痫(AE)是一种常见的非病灶性癫痫。本研究旨在研究通过支持向量机（SVM）方法评估的区域同质性（ReHo）的临床诊断实用性，以识别AE。
方法：本研究涉及102名健康个体和93名AE患者。所有参与者均采用静息状态功能磁共振成像进行数据采集。ReHo分析,再加上SVM方法，用于数据处理。
结果：与健康对照组相比，AE患者在双侧壳核表现出显著升高的ReHo值,伴有双侧丘脑ReHo减少。基于rs-fMRI数据,使用SVM来区分患有AE的患者与健康对照个体。对左壳核和左丘脑中改变的ReHo的综合评估得出的最高准确度为81.64％，敏感性为95.41%，特异性为69.23%。
结论：根据结果，双侧壳核和丘脑中ReHo值的改变可以作为AE的神经影像学标志物，为其诊断提供客观指导。
方法：本研究涉及102名健康个体和93名AE患者。所有参与者均采用静息状态功能磁共振成像进行数据采集。ReHo分析,再加上SVM方法，用于数据处理。
结果：与健康对照组相比，AE患者在双侧壳核表现出显著升高的ReHo值,伴有双侧丘脑ReHo减少。基于rs-fMRI数据,使用SVM来区分患有AE的患者与健康对照个体。对左壳核和左丘脑中改变的ReHo的综合评估得出的最高准确度为81.64％，敏感性为95.41%，特异性为69.23%。
结论：根据结果，双侧壳核和丘脑中ReHo值的改变可以作为AE的神经影像学标志物，为其诊断提供客观指导。
