Abstract：
In sexually mature male Wistar rats with modeled post-traumatic stress disorder, personalized characteristics of neurobiological reactions in the population of predator-induced stress-resilient and stress-susceptible heparinized animals were determined. Characteristics of the systemic response of immune mechanisms, hypothalamic-pituitary-adrenal axis, behavioral manifestations, as well as basic properties of the CNS (excitation/inhibition) are presented. The study demonstrated encouraging positive results of the course administration of unfractionated heparin at a dose below the therapeutic and prophylactic doses. The inclusion of heparin drugs into the clinical practice for the treatment of post-traumatic stress disorder will not require large-scale clinical trials, because many effects of heparin as a nonspecific adaptogen are well studied. Moreover, these properties were confirmed at a higher technological level during the COVID-19 pandemic.
摘要：
在具有创伤后应激障碍模型的性成熟雄性Wistar大鼠中，我们确定了捕食者诱导的应激弹性和应激易感肝素化动物群体中神经生物学反应的个性化特征.免疫机制的全身反应的特征，下丘脑-垂体-肾上腺轴,行为表现，以及CNS的基本特性（激发/抑制）。该研究证明了以低于治疗和预防剂量的剂量给药普通肝素的过程中令人鼓舞的积极结果。将肝素药物纳入治疗创伤后应激障碍的临床实践不需要大规模的临床试验,因为肝素作为一种非特异性适应原的许多作用都得到了充分的研究。此外，在COVID-19大流行期间，这些特性在更高的技术水平上得到了证实。
