{Reference Type}: Journal Article
{Title}: Heparin as a Potential Therapeutic Substance for Post-Traumatic Stress Disorder.
{Author}: Kondashevskaya MV;Artemyeva KA;Aleksankina VV;Mikhaleva LM;
{Journal}: Bull Exp Biol Med
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 2
{Factor}: 0.737
{DOI}: 10.1007/s10517-024-06120-0
{Abstract}: In sexually mature male Wistar rats with modeled post-traumatic stress disorder, personalized characteristics of neurobiological reactions in the population of predator-induced stress-resilient and stress-susceptible heparinized animals were determined. Characteristics of the systemic response of immune mechanisms, hypothalamic-pituitary-adrenal axis, behavioral manifestations, as well as basic properties of the CNS (excitation/inhibition) are presented. The study demonstrated encouraging positive results of the course administration of unfractionated heparin at a dose below the therapeutic and prophylactic doses. The inclusion of heparin drugs into the clinical practice for the treatment of post-traumatic stress disorder will not require large-scale clinical trials, because many effects of heparin as a nonspecific adaptogen are well studied. Moreover, these properties were confirmed at a higher technological level during the COVID-19 pandemic.