%0 Journal Article
%T Heparin as a Potential Therapeutic Substance for Post-Traumatic Stress Disorder.
%A Kondashevskaya MV
%A Artemyeva KA
%A Aleksankina VV
%A Mikhaleva LM
%J Bull Exp Biol Med
%V 0
%N 0
%D 2024 Jul 2
%M 38954296
%F 0.737
%R 10.1007/s10517-024-06120-0
%X In sexually mature male Wistar rats with modeled post-traumatic stress disorder, personalized characteristics of neurobiological reactions in the population of predator-induced stress-resilient and stress-susceptible heparinized animals were determined. Characteristics of the systemic response of immune mechanisms, hypothalamic-pituitary-adrenal axis, behavioral manifestations, as well as basic properties of the CNS (excitation/inhibition) are presented. The study demonstrated encouraging positive results of the course administration of unfractionated heparin at a dose below the therapeutic and prophylactic doses. The inclusion of heparin drugs into the clinical practice for the treatment of post-traumatic stress disorder will not require large-scale clinical trials, because many effects of heparin as a nonspecific adaptogen are well studied. Moreover, these properties were confirmed at a higher technological level during the COVID-19 pandemic.