PDF(Pubmed)
Abstract：
This study investigates the effectiveness of multiple COVID-19 vaccinations on daily confirmed cases in Seoul City. Utilizing comprehensive data on vaccinated individuals and confirmed cases sourced from the official website of the Korean Ministry of the Interior and Safety, we conducted detailed statistical analyses to assess the impact of each vaccination dose. The study covers data from April 21, 2021, to September 29, 2022. Statistical multiple linear regression was employed to analyze the relationship between daily confirmed cases (positive outcomes from PCR tests) and multiple vaccine doses, using p-values as the criteria for determining the effectiveness of each dose. The analysis included data from four vaccination doses. The analysis reveals that the first, second, and third doses of the COVID-19 vaccines have a statistically significant positive effect associated with the daily confirmed cases. However, the study finds that the fourth dose does not show a statistically significant impact on the reduction of daily confirmed cases. This suggests that while the initial three doses are crucial for establishing and maintaining high levels of immunity, the incremental benefit of subsequent doses may diminish.
摘要：
这项研究调查了首尔市每日确诊病例多次接种COVID-19疫苗的有效性。利用来自韩国内政和安全部官方网站的有关接种疫苗的个人和确诊病例的全面数据，我们进行了详细的统计分析,以评估每次疫苗接种剂量的影响.该研究涵盖了2021年4月21日至2022年9月29日的数据。统计多元线性回归分析每日确诊病例（PCR检测阳性结果）与多剂量疫苗之间的关系，使用p值作为确定每个剂量有效性的标准。分析包括来自四个疫苗接种剂量的数据。分析表明，第一，第二,第三剂COVID-19疫苗与每日确诊病例相关，具有统计学显著的正效应。然而,研究发现，第四剂对减少每日确诊病例没有统计学意义。这表明，尽管最初的三个剂量对于建立和维持高水平的免疫力至关重要，后续剂量的增量益处可能会减少。
