PDF(Pubmed)
Abstract：
BACKGROUND: Pulmonary aspergillosis is a prevalent opportunistic fungal infection that can lead to mortality in pediatric patients with underlying immunosuppression. Appropriate and timely treatment of pulmonary aspergillosis can play a crucial role in reducing mortality among children admitted with suspected infections.
METHODS: The present study reports three cases of inappropriate treatment of pulmonary aspergillosis caused by Aspergillus flavus in two Iranian pediatric patients under investigation and one Afghan patient. Unfortunately, two of them died. The cases involved patients aged 9, 1.5, and 3 years. They had been diagnosed with pulmonary disorders, presenting nonspecific clinical signs and radiographic images suggestive of pneumonia. The identification of A. flavus was confirmed through DNA sequencing of the calmodulin (CaM) region.
CONCLUSIONS: A. flavus was the most prevalent cause of pulmonary aspergillosis in pediatric patients. Early diagnosis and accurate antifungal treatment of pulmonary aspergillosis could be crucial in reducing the mortality rate and also have significant potential for preventing other complications among children. Moreover, antifungal prophylaxis seems to be essential for enhancing survival in these patients.
METHODS: The present study reports three cases of inappropriate treatment of pulmonary aspergillosis caused by Aspergillus flavus in two Iranian pediatric patients under investigation and one Afghan patient. Unfortunately, two of them died. The cases involved patients aged 9, 1.5, and 3 years. They had been diagnosed with pulmonary disorders, presenting nonspecific clinical signs and radiographic images suggestive of pneumonia. The identification of A. flavus was confirmed through DNA sequencing of the calmodulin (CaM) region.
CONCLUSIONS: A. flavus was the most prevalent cause of pulmonary aspergillosis in pediatric patients. Early diagnosis and accurate antifungal treatment of pulmonary aspergillosis could be crucial in reducing the mortality rate and also have significant potential for preventing other complications among children. Moreover, antifungal prophylaxis seems to be essential for enhancing survival in these patients.
摘要：
背景：肺曲霉病是一种普遍的机会性真菌感染，可导致潜在免疫抑制的儿科患者死亡。适当和及时的治疗肺曲霉病可以在降低可疑感染儿童死亡率方面发挥关键作用。
方法：本研究报告了2例伊朗儿科患者和1例阿富汗患者中3例黄曲霉引起的肺曲霉病治疗不当的病例。不幸的是,其中两人死亡。这些病例涉及9岁、1.5岁和3岁的患者。他们被诊断出患有肺部疾病，呈现非特异性临床体征和影像学图像提示肺炎。通过钙调蛋白（CaM）区域的DNA测序证实了黄曲霉的鉴定。
结论：A.黄质是儿科患者肺曲霉病的最常见原因。肺曲霉病的早期诊断和准确的抗真菌治疗对于降低死亡率至关重要，并且在预防儿童其他并发症方面也具有巨大潜力。此外，抗真菌预防似乎对提高这些患者的生存率至关重要.
方法：本研究报告了2例伊朗儿科患者和1例阿富汗患者中3例黄曲霉引起的肺曲霉病治疗不当的病例。不幸的是,其中两人死亡。这些病例涉及9岁、1.5岁和3岁的患者。他们被诊断出患有肺部疾病，呈现非特异性临床体征和影像学图像提示肺炎。通过钙调蛋白（CaM）区域的DNA测序证实了黄曲霉的鉴定。
结论：A.黄质是儿科患者肺曲霉病的最常见原因。肺曲霉病的早期诊断和准确的抗真菌治疗对于降低死亡率至关重要，并且在预防儿童其他并发症方面也具有巨大潜力。此外，抗真菌预防似乎对提高这些患者的生存率至关重要.
