Abstract：
Approximately one third of the population is prone to motion sickness (MS), which is associated with the dysfunction in the integration of sensory inputs. Transcranial alternating current stimulation (tACS) has been widely used to modulate neurological functions by affecting neural oscillation. However, it has not been applied in the treatment of motion sickness. This study aims to investigate changes in brain oscillations during exposure to MS stimuli and to further explore the potential impact of tACS with the corresponding frequency and site on MS symptoms. A total of 19 subjects were recruited to be exposed to Coriolis stimuli to complete an inducing session. After that, they were randomly assigned to tACS stimulation group or sham stimulation group to complete a stimulation session. Electroencephalography (EEG), electrocardiogram, and galvanic skin response were recorded during the experiment. All the subjects suffering from obvious MS symptoms after inducing session were observed that alpha power of four channels of parieto-occipital lobe significantly decreased (P7: t =3.589, p <0.001; P8: t =2.667, p <0.05; O1: t =3.556, p <0.001; O2: t =2.667, p <0.05). Based on this, tACS group received the tACS stimulation at 10Hz from Oz to CPz. Compared to sham group, tACS stimulation significantly improved behavioral performance and entrained the alpha oscillation in individuals whose alpha power decrease during the inducing session. The findings show that parieto-occipital alpha oscillation plays a critical role in the integration of sensory inputs, and alpha tACS on parieto-occipital can become a potential method to mitigate MS symptoms.
摘要：
大约三分之一的人口容易患晕动病（MS），这与感觉输入整合的功能障碍有关。经颅交流电流刺激（tACS）已被广泛用于通过影响神经振荡来调节神经功能。然而,它尚未应用于晕车的治疗。这项研究旨在研究暴露于MS刺激期间脑振荡的变化，并进一步探讨tACS对MS症状的相应频率和部位的潜在影响。招募总共19名受试者暴露于科里奥利刺激以完成诱导期。之后,他们被随机分配到tACS刺激组和假刺激组,以完成刺激疗程.脑电图(EEG),心电图,在实验过程中记录皮肤电反应。诱导后所有患有明显MS症状的受试者均观察到顶枕叶四个通道的α功率显着降低（P7：t=3.589，p<0.001；P8：t=2.667，p<0.05；O1：t=3.556，p<0.001；O2：t=2.667，p<0.05）。基于此,tACS组接受从Oz到CPz的10Hz的tACS刺激。与假手术组相比，tACS刺激显着改善了行为表现，并在诱导期α功率降低的个体中引起了α振荡。研究结果表明，顶枕骨α振荡在感觉输入的整合中起着至关重要的作用，顶枕骨上的αtACS可以成为减轻MS症状的潜在方法。
