Abstract：
The use of animal models is still widespread in science but there is a movement away from this manner of experimentation. One option approved by the FDA for human-like studies is the hollow fiber bioreactor (HFS). HFSs are highly controllable, self-contained systems that allow for the modeling of individual tissues and disease phenotypes. Oxygen, drug concentration & half-life, and immune cell invasion are all scalable to human and veterinary conditions using a HFS. There are drawbacks to the systems including cost and contamination so the use of these systems must be carefully managed.With these limitations in mind, the scope of the technology is great. Antimicrobial susceptibility testing (AST) is possible with greater accuracy and clinical validity than classical in vitro techniques making minimal inhibitory concentration (MIC) data generated on the bench more translatable to the clinic.In this chapter, we will outline the background of the HFS and some typical uses.
摘要：
动物模型的使用在科学中仍然很普遍，但是这种实验方式有一种运动。FDA批准的用于类似人类研究的一种选择是中空纤维生物反应器(HFS)。HFS是高度可控的，独立的系统，允许对个体组织和疾病表型进行建模。氧气,药物浓度和半衰期，和免疫细胞侵袭都可以使用HFS扩展到人类和兽医条件。该系统存在包括成本和污染的缺点,因此必须仔细管理这些系统的使用。考虑到这些限制，该技术的范围很大。与经典的体外技术相比，抗菌素敏感性测试（AST）可以具有更高的准确性和临床有效性，从而使在工作台上产生的最小抑制浓度（MIC）数据更易于转化为临床。在这一章中,我们将概述HFS的背景和一些典型用途。
