Abstract：
Complexity in biology is often described using a multi-map hierarchical architecture, where the genotype, representing the encoded information, is mapped to the functional level, known as the phenotype, which is then connected to a latent phenotype we refer to as fitness. This underlying architecture governs the processes driving evolution. Furthermore, natural selection, along with other neutral forces, can, in turn, modify these maps. At each level, variation is observed. Here, I propose the need to establish principles that can aid in understanding the transformation of variation within this multi-map architecture. Specifically, I will introduce three, related to the presence of modulators, constraints, and the modular channeling of variation. By comprehending these design principles in various biological systems, we can gain better insights into the mechanisms underlying these maps and how they ultimately contribute to evolutionary dynamics.
摘要：
生物学中的复杂性通常使用多地图分层结构来描述，基因型，表示编码信息，映射到功能级别，被称为表型，然后与我们称为适应度的潜在表型有关。这个底层架构控制着推动进化的过程。此外，自然选择,以及其他中立力量，可以，反过来,修改这些地图。在每个级别,观察到变化。这里,我建议需要建立可以帮助理解这种多地图体系结构中的变化转换的原则。具体来说,我将介绍三，与调节剂的存在有关，约束，和变化的模块化通道。通过在各种生物系统中理解这些设计原则，我们可以更好地了解这些地图背后的机制，以及它们最终如何促进进化动力学。
