Abstract：
Diabetes is an epidemic caused by a multitude of factors. Despite the studies attempting to unravel its mechanism, there is still more to discover about glucose-insulin dynamics. In a recent issue of the Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β-cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β-cells.Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β-cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β-cells. Their multiomics approach might provide a deeper understanding of high glucose and translational regulation of genes involved in β-cell insulin impairment caused by prolonged high-glucose exposure.
摘要：
糖尿病是由多种因素引起的流行病。尽管有研究试图揭示其机制，关于葡萄糖-胰岛素动力学还有更多的发现。在最近一期的《临床研究杂志》上，Cheruiyot等人。揭示了β细胞葡萄糖毒性过程中的翻译调节回路，该回路固有地影响了功能性β细胞中的翻译组成和蛋白质表达。临床研究杂志，Cheruiyot等人。揭示了β细胞葡萄糖毒性过程中的翻译调节回路，该回路固有地影响了功能性β细胞中的翻译组成和蛋白质表达。他们的多组学方法可能会更深入地了解高糖和与长时间高糖暴露引起的β细胞胰岛素损伤有关的基因的翻译调节。
