{Reference Type}: Journal Article
{Title}: A sneak peek into chronic glucose exposure and insulin secretion impairment through translatome.
{Author}: Helena GA;Kume S;
{Journal}: J Diabetes Investig
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 1
{Factor}: 3.681
{DOI}: 10.1111/jdi.14258
{Abstract}: Diabetes is an epidemic caused by a multitude of factors. Despite the studies attempting to unravel its mechanism, there is still more to discover about glucose-insulin dynamics. In a recent issue of the Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β-cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β-cells.Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β-cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β-cells. Their multiomics approach might provide a deeper understanding of high glucose and translational regulation of genes involved in β-cell insulin impairment caused by prolonged high-glucose exposure.