%0 Journal Article
%T A sneak peek into chronic glucose exposure and insulin secretion impairment through translatome.
%A Helena GA
%A Kume S
%J J Diabetes Investig
%V 0
%N 0
%D 2024 Jul 1
%M 38949390
%F 3.681
%R 10.1111/jdi.14258
%X Diabetes is an epidemic caused by a multitude of factors. Despite the studies attempting to unravel its mechanism, there is still more to discover about glucose-insulin dynamics. In a recent issue of the Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β-cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β-cells.Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β-cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β-cells. Their multiomics approach might provide a deeper understanding of high glucose and translational regulation of genes involved in β-cell insulin impairment caused by prolonged high-glucose exposure.