PDF(Pubmed)
Abstract：
Substance use disorders (SUDs) are seen as a continuum ranging from goal-directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on Losing and Regaining Control over Drug Intake (ReCoDe) are (i) to study triggers (drug cues, stressors, drug priming) and modifying factors (age, gender, physical activity, cognitive functions, childhood adversity, social factors, such as loneliness and social contact/interaction) that longitudinally modulate the trajectories of losing and regaining control over drug consumption under real-life conditions. (ii) To study underlying behavioural, cognitive and neurobiological mechanisms of disease trajectories and drug-related behaviours and (iii) to provide non-invasive mechanism-based interventions. These goals are achieved by: (A) using innovative mHealth (mobile health) tools to longitudinally monitor the effects of triggers and modifying factors on drug consumption patterns in real life in a cohort of 900 patients with alcohol use disorder. This approach will be complemented by animal models of addiction with 24/7 automated behavioural monitoring across an entire disease trajectory; i.e. from a naïve state to a drug-taking state to an addiction or resilience-like state. (B) The identification and, if applicable, computational modelling of key molecular, neurobiological and psychological mechanisms (e.g., reduced cognitive flexibility) mediating the effects of such triggers and modifying factors on disease trajectories. (C) Developing and testing non-invasive interventions (e.g., Just-In-Time-Adaptive-Interventions (JITAIs), various non-invasive brain stimulations (NIBS), individualized physical activity) that specifically target the underlying mechanisms for regaining control over drug intake. Here, we will report on the most important results of the first funding period and outline our future research strategy.
摘要：
物质使用障碍（SUD）被视为一个连续体，从目标导向和享乐主义的药物使用到对药物摄入失去控制，对身心健康和社会功能产生不利影响。我们的跨学科德国合作研究中心的主要目标是（i）研究触发因素（药物线索，压力源,药物启动)和修饰因素(年龄，性别,身体活动,认知功能，童年的逆境,社会因素,例如孤独和社交接触/互动），纵向调节在现实生活条件下失去和重新控制药物消费的轨迹。(二)研究潜在的行为，疾病轨迹和药物相关行为的认知和神经生物学机制，以及（iii）提供基于非侵入性机制的干预措施。这些目标通过以下方式实现：（A）使用创新的mHealth（移动健康）工具，在900名酒精使用障碍患者的队列中，纵向监测现实生活中触发因素和改变因素对药物消费模式的影响。这种方法将得到成瘾动物模型的补充，在整个疾病轨迹上进行24/7自动化行为监测;即从幼稚状态到吸毒状态再到成瘾或弹性状态。(B)识别和如果适用，关键分子的计算建模，神经生物学和心理机制(例如，认知灵活性降低)调解此类触发因素和改变因素对疾病轨迹的影响。(C)开发和测试非侵入性干预措施(例如，即时自适应干预(JITAI)，各种非侵入性脑刺激（NIBS），个性化的身体活动），专门针对重新控制药物摄入的潜在机制。这里,我们将报告第一个资助期最重要的成果，并概述我们未来的研究策略。
