PDF(Pubmed)
Abstract：
UNASSIGNED: Polycystic ovary syndrome (PCOS) is both a common endocrine syndrome and a metabolic disorder that results in harm to the reproductive system and whole-body metabolism. This study aimed to investigate differences in the serum metabolic profiles of patients with PCOS compared with healthy controls, in addition to investigating the effects of compound oral contraceptive (COC) treatment in patients with PCOS.
UNASSIGNED: 50 patients with PCOS and 50 sex-matched healthy controls were recruited. Patients with PCOS received three cycles of self-administered COC treatment. Clinical characteristics were recorded, and the laboratory biochemical data were detected. We utilized ultra-performance liquid chromatography-high-resolution mass spectrometry to study the serum metabolic changes between patients with PCOS, patients with PCOS following COC treatment, and healthy controls.
UNASSIGNED: Patients with PCOS who received COC treatment showed significant improvements in serum sex hormone levels, a reduction in luteinising hormone levels, and a significant reduction in the levels of biologically active free testosterone in the blood. Differential metabolite correlation analysis revealed differences between PCOS and healthy control groups in N-tetradecanamide, hexadecanamide, 10E,12Z-octadecadienoic acid, and 13-HOTrE(r); after 3 months of COC treatment, there were significant differences in benzoic acid, organic acid, and phenolamides. Using gas chromatography-mass spectrometry to analyse blood serum in each group, the characteristic changes in PCOS were metabolic disorders of amino acids, carbohydrates, and purines, with significant changes in the levels of total cholesterol, uric acid, phenylalanine, aspartic acid, and glutamate.
UNASSIGNED: Following COC treatment, improvements in sex hormone levels, endocrine factor levels, and metabolic levels were better than in the group of PCOS patients receiving no COC treatment, indicating that COC treatment for PCOS could effectively regulate the levels of sex hormones, endocrine factors, and serum metabolic profiles.
UNASSIGNED: 50 patients with PCOS and 50 sex-matched healthy controls were recruited. Patients with PCOS received three cycles of self-administered COC treatment. Clinical characteristics were recorded, and the laboratory biochemical data were detected. We utilized ultra-performance liquid chromatography-high-resolution mass spectrometry to study the serum metabolic changes between patients with PCOS, patients with PCOS following COC treatment, and healthy controls.
UNASSIGNED: Patients with PCOS who received COC treatment showed significant improvements in serum sex hormone levels, a reduction in luteinising hormone levels, and a significant reduction in the levels of biologically active free testosterone in the blood. Differential metabolite correlation analysis revealed differences between PCOS and healthy control groups in N-tetradecanamide, hexadecanamide, 10E,12Z-octadecadienoic acid, and 13-HOTrE(r); after 3 months of COC treatment, there were significant differences in benzoic acid, organic acid, and phenolamides. Using gas chromatography-mass spectrometry to analyse blood serum in each group, the characteristic changes in PCOS were metabolic disorders of amino acids, carbohydrates, and purines, with significant changes in the levels of total cholesterol, uric acid, phenylalanine, aspartic acid, and glutamate.
UNASSIGNED: Following COC treatment, improvements in sex hormone levels, endocrine factor levels, and metabolic levels were better than in the group of PCOS patients receiving no COC treatment, indicating that COC treatment for PCOS could effectively regulate the levels of sex hormones, endocrine factors, and serum metabolic profiles.
摘要：
■多囊卵巢综合征（PCOS）既是一种常见的内分泌综合征，也是一种代谢紊乱，会对生殖系统和全身代谢造成伤害。本研究旨在探讨PCOS患者与健康对照组血清代谢谱的差异。除了研究复方口服避孕药（COC）治疗对PCOS患者的影响。
■招募了50名PCOS患者和50名性别匹配的健康对照。PCOS患者接受三个周期的自我给药COC治疗。记录临床特征，并检测了实验室生化数据。我们利用超高效液相色谱-高分辨率质谱来研究PCOS患者之间的血清代谢变化。COC治疗后的PCOS患者，和健康的控制。
接受COC治疗的PCOS患者血清性激素水平显着改善，黄体激素水平的降低，血液中生物活性游离睾酮水平显著降低。差异代谢相关分析显示PCOS和健康对照组在N-十四酰胺，十六酰胺,10E,12Z-十八碳二烯酸,和13-HOTrE（r）；COC治疗3个月后，苯甲酸存在显著差异，有机酸,和酚酰胺.采用气相色谱-质谱法对各组血清进行分析,PCOS的特征性变化是氨基酸代谢紊乱，碳水化合物,还有嘌呤,随着总胆固醇水平的显著变化，尿酸,苯丙氨酸,天冬氨酸,还有谷氨酸.
■COC治疗后，性激素水平的改善，内分泌因子水平，和代谢水平优于未接受COC治疗的PCOS患者组，说明COC治疗PCOS能有效调节性激素水平,内分泌因素，和血清代谢谱。
■招募了50名PCOS患者和50名性别匹配的健康对照。PCOS患者接受三个周期的自我给药COC治疗。记录临床特征，并检测了实验室生化数据。我们利用超高效液相色谱-高分辨率质谱来研究PCOS患者之间的血清代谢变化。COC治疗后的PCOS患者，和健康的控制。
接受COC治疗的PCOS患者血清性激素水平显着改善，黄体激素水平的降低，血液中生物活性游离睾酮水平显著降低。差异代谢相关分析显示PCOS和健康对照组在N-十四酰胺，十六酰胺,10E,12Z-十八碳二烯酸,和13-HOTrE（r）；COC治疗3个月后，苯甲酸存在显著差异，有机酸,和酚酰胺.采用气相色谱-质谱法对各组血清进行分析,PCOS的特征性变化是氨基酸代谢紊乱，碳水化合物,还有嘌呤,随着总胆固醇水平的显著变化，尿酸,苯丙氨酸,天冬氨酸,还有谷氨酸.
■COC治疗后，性激素水平的改善，内分泌因子水平，和代谢水平优于未接受COC治疗的PCOS患者组，说明COC治疗PCOS能有效调节性激素水平,内分泌因素，和血清代谢谱。
